Phospholipase A2 receptor IgG Ab [Presence] in Serum by Line blot
This term was created for, but is not limited in use to, the submitter's test strip, a membrane strip pre-coated with a specific set of antigens in parallel lines. If antibodies to any of those antigens are present in the patient's serum, they will bind to the specific antigen. The bound patient antibodies are then detected using labelled anti-human antibodies. Various manufacturers classify this method as an immunoblot technique. LOINC uses the immunoblot (IB) method to mean that some electrophoretic/chromatographic separation occurs such that position (size) of the band is part of the assessment (as in Western blot). Because this assay does not involve a separation step but rather uses strips with pre-fixed antigens, the LOINC Method is Line blot.
Source: Regenstrief LOINC
LP172674-6 Phospholipase A2 receptor Ab.IgG
The M-type phospholipase A2 receptor (PLA2R) stimulates the production of phospholipase A2 receptor autoantibodies. The PLA2R antibodies are a sensitive biomarker for idiopathic membranous nephropathy (MN). Over 80% of patients with MN are positive for PLA2R antibodies. MN is a syndrome where immune complexes deposit on the basement membrane and along with complement fixation alter the filtration barrier leading to proteinuria. The target antigens reside on the podocytes and is where the disease process begins. PLA2R antibodies are useful to diagnose and monitor treatment of MN. PMCID: PMC3103733 Source: Regenstrief LOINC
- Phospholipase A2 receptor Ab.IgG
- Line blot
- Short Name
- PLA2R IgG Ser Ql Line blot
- Display Name
- Phospholipase A2 receptor IgG Line blot Ql (S)
- Consumer Name Alpha Get Info
- Phospholipase A2 Receptor IgG antibody, Blood
Example Answer List: LL360-9Source: Regenstrief Institute
|PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value)||LA6576-8|
|NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value)||LA6577-6|
- First Released
- Version 2.58
- Last Updated
- Version 2.66
- Change Reason
- This term was created for an assay that uses a membrane strip pre-coated with a specific set of antigens in parallel lines. Because the antigens are seperated by electrophoresis/chromatographic separation during manufacturing, not during the test procedure itself, this test was assigned a LOINC Method of Immunoassay (IA) and not Immunoblot (IB). However, upon further review of IA, IB, and Immunoblot strip methodologies and regulatory distinctions between these, we changed the Method from IA to Line blot so that users can distinguish between these three Methods. The meaning of the term has not changed since it was created for an IB strip assay as described in the term description.
- Order vs. Observation
Member of these Groups Get Info
|LOINC Group||Group Name|
|LG31602-2||Phospholipase A2 receptor Ab.IgG|
Language Variants Get Info
|es-ES||Spanish (Spain)||Receptor fosfolipasa A2 IgG:
|es-MX||Spanish (Mexico)||Receptor de fosfolipasa A2 Ab.IgG:
|fr-FR||French (France)||Phospholipase A2 récepteur anticorps IgG:
|it-IT||Italian (Italy)||Fosfolipasi, recettore a2 Ab.IgG:
Synonyms: anticorpi IgG anticorpo Presenza o Soglia Punto nel tempo (episodio) Recettore della fosfolipasi A2 Siero Sierologia (anticorpi e la maggior parte degli ant
|nl-NL||Dutch (Netherlands)||fosfolipase A2-receptor As.IgG:
|zh-CN||Chinese (China)||磷脂酶 A2 受体 抗体.IgG:
Synonyms: A2 型 Ab.IgG;
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