LOINC
Version 2.67

82995-2TIF1-gamma IgG Ab [Presence] in Serum by Line blotActive

Term Description

This term was created for, but is not limited in use to, the submitter's test strip, a membrane strip pre-coated with a specific set of antigens in parallel lines. If antibodies to any of those antigens are present in the patient's serum, they will bind to the specific antigen. The bound patient antibodies are then detected using labelled anti-human antibodies. Various manufacturers classify this method as an immunoblot technique. LOINC uses the immunoblot (IB) method to mean that some electrophoretic/chromatographic separation occurs such that position (size) of the band is part of the assessment (as in Western blot). Because this assay does not involve a separation step but rather uses strips with pre-fixed antigens, the LOINC Method is Line blot.
Source: Regenstrief LOINC

Part Descriptions

LP220413-1   TIF1-gamma
Transcriptional intermediary factor 1-gamma (TIF1-gamma or E3 ubiquitin-protein ligase TRIM33), induces inactivation of the SMAD4 protein, which promotes cell growth (including malignant tumours) by inhibiting the anti-proliferative effects of TGF-beta. Anti-TIF1-gamma autoantibodies have been associated with adult- and juvenile-onset dermatomyositis (DM), and particularly with cancer-associated DM. [PMID: 20501546] Source: Regenstrief LOINC, PMID: 20501546

LP230512-8   TIF1-gamma Ab.IgG
The autoantibody transcription intermediary factor 1-gamma (also known as anti-TIF1- γ, anti-p155 and anti-TRIM33) is recognized as a useful biomarker to assist in diagnosing cancer-associated myositis (CAM) in adult patients. (2006, p155 was identified as transcription intermediary factor 1γ (TIF-1γ)) Source: Regenstrief LOINC

Fully-Specified Name

Component
TIF1-gamma Ab.IgG
Property
PrThr
Time
Pt
System
Ser
Scale
Ord
Method
Line blot

Additional Names

Short Name
TIF1-gamma IgG Ser Ql Line blot
Display Name
TIF1-gamma IgG Line blot Ql (S)

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.58
Last Updated
Version 2.66
Change Reason
This term was created for an assay that uses a membrane strip pre-coated with a specific set of antigens in parallel lines. Because the antigens are seperated by electrophoresis/chromatographic separation during manufacturing, not during the test procedure itself, this test was assigned a LOINC Method of Immunoassay (IA) and not Immunoblot (IB). However, upon further review of IA, IB, and Immunoblot strip methodologies and regulatory distinctions between these, we changed the Method from IA to Line blot so that users can distinguish between these three Methods. The meaning of the term has not changed since it was created for an IB strip assay as described in the term description.
Order vs. Observation
Both

Example Answer List LL360-9

Source: Regenstrief Institute

Answer Code Score Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Language Variants Get Info

zh-CNChinese (CHINA)
TIF1-gamma 抗体.IgG:存在情况或阈值:时间点:血清:序数型:线点印迹法
nl-NLDutch (NETHERLANDS)
TIF1-gamma As.IgG:aanwezigheid:moment:serum:ordinaal:lijnblot
fr-FRFrench (FRANCE)
TIF1 gamma anticorps IgG:Présence/Seuil:Ponctuel:Sérum:Qualitatif:Blot en ligne
es-ESSpanish (SPAIN)
TIF1-gamma IgG:PrThr:Punto temporal:Suero:Ord:Line blot

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=82995-2