Version 2.73

82998-6Dense fine speckled 70 protein IgG Ab [Presence] in Serum or Plasma by Line blotActive

Term Description

This term was created for, but is not limited in use to, the submitter's test strip, a membrane strip pre-coated with a specific set of antigens in parallel lines. If antibodies to any of those antigens are present in the patient's serum, they will bind to the specific antigen. The bound patient antibodies are then detected using labelled anti-human antibodies. Various manufacturers classify this method as an immunoblot technique. LOINC uses the immunoblot (IB) method to mean that some electrophoretic/chromatographic separation occurs such that position (size) of the band is part of the assessment (as in Western blot). Because this assay does not involve a separation step but rather uses strips with pre-fixed antigens, the LOINC Method is Line blot.
Source: Regenstrief LOINC

Part Description

LP230331-3   Dense fine speckled 70 protein Ab.IgG
Antinuclear antibodies are essential to diagnose systemic autoimmune rheumatic diseases (SARDs) such as Lupus erythematosus and scleroderma. However, 20-30% of healthy people test positive for ANAs,half of which are dense fine speckled 70 protein (DFS70) antibodies. DFS70 antibodies have been found in patients with various chronic inflammatory diseases but no one disease in particular. It has been suggested that the best use for measuring DFS70 antibodies might be as a biomarker that excludes the diagnosis of SARD since DFS70 antibodies are more often found in patients without active SARD than with it. Antibody titers of DFS70 are highest in healthy young females and the titers decline as a person ages.( http://cli-online.com/featured-articles/anti-dfs70-antibodies-detection-and-significance/) Copyright Copyright 2001-2019 American Association for Clinical Chemistry. Source: Regenstrief LOINC

Fully-Specified Name

Dense fine speckled 70 protein Ab.IgG
Line blot

Additional Names

Short Name
DFS70 IgG SerPl Ql Line blot
Display Name
Dense fine speckled 70 protein IgG Line blot Ql
Consumer Name Alpha
Dense fine speckled 70 protein IgG antibody, Blood

Example Answer List LL360-9

Source: Regenstrief Institute

Answer Code Score Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Basic Attributes

First Released
Version 2.58
Last Updated
Version 2.66
Change Reason
This term was created for an assay that uses a membrane strip pre-coated with a specific set of antigens in parallel lines. Because the antigens are seperated by electrophoresis/chromatographic separation during manufacturing, not during the test procedure itself, this test was assigned a LOINC Method of Immunoassay (IA) and not Immunoblot (IB). However, upon further review of IA, IB, and Immunoblot strip methodologies and regulatory distinctions between these, we changed the Method from IA to Line blot so that users can distinguish between these three Methods. The meaning of the term has not changed since it was created for an IB strip assay as described in the term description.
Order vs. Observation

Member of these Groups

LG50952-7 Dense fine speckled 70 protein Ab.IgG|PrThr|Pt|ANYBldSerPl

Language Variants Get Info

zh-CNChinese (China)
致密细斑 70 蛋白 抗体.IgG:存在情况或阈值:时间点:血清/血浆:序数型:线点印迹法
nl-NLDutch (Netherlands)
dense fine speckled 70 protein As.IgG:aanwezigheid:moment:serum of plasma:ordinaal:lijnblot
fr-FRFrench (France)
DFS70 anticorps IgG:Présence/Seuil:Ponctuel:Sérum/Plasma:Qualitatif:Blot en ligne
it-ITItalian (Italy)
Proteina 70 densa fine punteggiata Ab.IgG:PrThr:Pt:Siero/Plasma:Ord:Line blot
es-MXSpanish (Mexico)
Ab.IgG de proteína 70 moteada fina y densa:Presencia o umbral:Punto temporal:Suero o Plasma:Ordinal:Mancha de línea
es-ESSpanish (Spain)
Proteína densa fina moteada 70 IgG:PrThr:Punto temporal:Suero o Plasma:Ord:Line blot

LOINC FHIR® API Example - CodeSystem Request Get Info