LOINC
Version 2.67

83002-6Zinc finger protein of the cerebellum 4 IgG Ab [Presence] in Serum or Plasma by Line blotActive

Term Description

This term was created for, but is not limited in use to, the submitter's test strip, a membrane strip pre-coated with a specific set of antigens in parallel lines. If antibodies to any of those antigens are present in the patient's serum, they will bind to the specific antigen. The bound patient antibodies are then detected using labelled anti-human antibodies. Various manufacturers classify this method as an immunoblot technique. LOINC uses the immunoblot (IB) method to mean that some electrophoretic/chromatographic separation occurs such that position (size) of the band is part of the assessment (as in Western blot). Because this assay does not involve a separation step but rather uses strips with pre-fixed antigens, the LOINC Method is Line blot.
Source: Regenstrief LOINC

Part Description

LP34979-2   Zinc finger protein of the cerebellum 4
Paraneoplastic neurological syndrome (PNS) is an autoimmune disorder that is manifested by progressive central, peripheral and/or autonomic nervous system symptoms. The neurological symptoms include encephalitis, autonomic failure, peripheral neuropathy, cerebellar ataxia, visual complaints and more. The antibodies that attack the neural tissue develop in response to tumor cells. The neoplasm may or may not be detectable using conventional imaging modalities. Since PNS can be associated with multiple antibodies testing usually includes a panel of PNS antibodies. In addition, the different PNS antibodies are associated with certain cancers so the antibody pattern can assist in identifying the specific tumor if it was previously undiagnosed. [PMID: 22412264] Of patients positive for the zinc finger protein of the cerebellum 4 (Zic4) antibodies, ninety-two percent were diagnosed with small cell lung cancer. Zic4 antibodies often occur concurrently with Hu and CRMP5 antibodies.[PMID: 15007130 Source: Regenstrief LOINC

Fully-Specified Name

Component
Zinc finger protein of the cerebellum 4 Ab.IgG
Property
PrThr
Time
Pt
System
Ser/Plas
Scale
Ord
Method
Line blot

Additional Names

Short Name
Zic4 IgG SerPl Ql Line blot
Display Name
Zinc finger protein of the cerebellum 4 IgG Line blot Ql

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.58
Last Updated
Version 2.66
Change Reason
This term was created for an assay that uses a membrane strip pre-coated with a specific set of antigens in parallel lines. Because the antigens are seperated by electrophoresis/chromatographic separation during manufacturing, not during the test procedure itself, this test was assigned a LOINC Method of Immunoassay (IA) and not Immunoblot (IB). However, upon further review of IA, IB, and Immunoblot strip methodologies and regulatory distinctions between these, we changed the Method from IA to Line blot so that users can distinguish between these three Methods. The meaning of the term has not changed since it was created for an IB strip assay as described in the term description.
Order vs. Observation
Both

Example Answer List LL360-9

Source: Regenstrief Institute

Answer Code Score Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Language Variants Get Info

zh-CNChinese (CHINA)
小脑锌指蛋白 4 抗体.IgG:存在情况或阈值:时间点:血清/血浆:序数型:线点印迹法
nl-NLDutch (NETHERLANDS)
zinc finger proteïne of the cerebellum 4 As.IgG:aanwezigheid:moment:serum of plasma:ordinaal:lijnblot
fr-CAFrench (CANADA)
Protéine à doigt de zinc du cervelet 4 , IgG:Présence-Seuil:Temps ponctuel:Sérum/Plasma:Ordinal:Immunoessai sur bandelette
fr-FRFrench (FRANCE)
Zic4 anticorps IgG:Présence/Seuil:Ponctuel:Sérum/Plasma:Qualitatif:Blot en ligne
es-ESSpanish (SPAIN)
Proteína dedo de zinc del cerebelo 4 IgG:PrThr:Punto temporal:Suero o Plasma:Ord:Line blot

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=83002-6