LOINC
Version 2.67

83003-4Recoverin IgG Ab [Presence] in Serum or Plasma by Line blotActive

Term Description

This term was created for, but is not limited in use to, the submitter's test strip, a membrane strip pre-coated with a specific set of antigens in parallel lines. If antibodies to any of those antigens are present in the patient's serum, they will bind to the specific antigen. The bound patient antibodies are then detected using labelled anti-human antibodies. Various manufacturers classify this method as an immunoblot technique. LOINC uses the immunoblot (IB) method to mean that some electrophoretic/chromatographic separation occurs such that position (size) of the band is part of the assessment (as in Western blot). Because this assay does not involve a separation step but rather uses strips with pre-fixed antigens, the LOINC Method is Line blot.
Source: Regenstrief LOINC

Part Description

LP222259-6   Recoverin
Recoverin is a calcium-binding photoreceptor protein that has been identified as the target of autoantibodies that results in cancer-associated retinopathy (CAR). CAR is a paraneoplastic syndrome where autoantibodies against an unknown neoplasm cross-react with retinal photoreceptor antigens and damage them leading to vision loss. [PMID: 7568096] Only 65% of patients with CAR have detectable antiretinal antibodies and antibodies specific to recoverin are found in approximately 10% of those patients. Most tumors associated with CAR include small-cell lung cancer and gynecological malignancies. Neoplasms that are less often associated with CAR include bladder, prostate, pancreatic, small bowel, thymus, thyroid and colon. [PMID: 26862417] Recoverin antibodies lead to cancer-associated retinopathy and have been shown to induce apoptotic death to photoreceptor cells. [PMID: 12417436] Source: Regenstrief LOINC

Fully-Specified Name

Component
Recoverin Ab.IgG
Property
PrThr
Time
Pt
System
Ser/Plas
Scale
Ord
Method
Line blot

Additional Names

Short Name
Recoverin IgG SerPl Ql Line blot
Display Name
Recoverin IgG Line blot Ql

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.58
Last Updated
Version 2.66
Change Reason
This term was created for an assay that uses a membrane strip pre-coated with a specific set of antigens in parallel lines. Because the antigens are seperated by electrophoresis/chromatographic separation during manufacturing, not during the test procedure itself, this test was assigned a LOINC Method of Immunoassay (IA) and not Immunoblot (IB). However, upon further review of IA, IB, and Immunoblot strip methodologies and regulatory distinctions between these, we changed the Method from IA to Line blot so that users can distinguish between these three Methods. The meaning of the term has not changed since it was created for an IB strip assay as described in the term description.
Order vs. Observation
Both

Example Answer List LL360-9

Source: Regenstrief Institute

Answer Code Score Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Language Variants Get Info

zh-CNChinese (CHINA)
恢复蛋白 抗体.IgG:存在情况或阈值:时间点:血清/血浆:序数型:线点印迹法
nl-NLDutch (NETHERLANDS)
recoverine As.IgG:aanwezigheid:moment:serum of plasma:ordinaal:lijnblot
fr-FRFrench (FRANCE)
Recovérine anticorps IgG:Présence/Seuil:Ponctuel:Sérum/Plasma:Qualitatif:Blot en ligne
es-ESSpanish (SPAIN)
Recoverina IgG:PrThr:Punto temporal:Suero o Plasma:Ord:Line blot

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=83003-4