Version 2.73

85835-7Beta-lactam resistance ESBL blaCTX-M-8+blaCTX-M-25 Group genes [Presence] by Molecular methodActive

Term Description

This term is used for assays that can detect, but not differentiate between the CTX-M-8 and CTX-M-25 extended spectrum beta lactamase genes in gram negative bacterial isolates. If either or both genes are positive, a single result of "positive" is reported. This term was created for, but is not limited in use to, the submitter's modified protocol for the Check-Points Check-MDR CT103XL assay.
Source: Regenstrief LOINC

Part Description

LP248281-0   Bacterial beta-lactam resistance ESBL blaCTX-M-8+blaCTX-M-25 Group genes
Extended-spectrum beta-lactamases (ESBL) are enzymes produced by some bacteria that are resistant to the majority of beta-lactam antibiotics which include the penicillins, cephalosporins and the monobactam aztreonam. [https://www.uptodate.com/contents/extended-spectrum-beta-lactamases] Organisms producing CTX-M type ESBL enzymes have been isolated worldwide with more than 150 enzymes identified. These enzymes have been classified into seven major phylogenetic groups: CTX-M -1, CTX-M-2, CTX-M-8, CTX-M-9, CTX-M-25, CTX-M-74 and CTX-M-75. The rare ESBL type CTX-M-8 has been isolated in Germany, mainly in E. coli, but also in Salmonella and E. aerogenes. CTX-M type ESBL have been isolated worldwide and their incidence has increased dramatically and is still increasing leading to a major therapeutic issue. Currently more than 150 allelic variants of CTX-M have been identified. These enzymes are classified in five major phylogenetic groups based on their gene sequences: CTX-M -1, CTX-M-2, CTX-M-8, CTX-M-9, CTX-M-25; two additional groups have been reported recently: CTX-M-74 and CTX-M-75. The dissemination of these enzymes has caused an increased use of carbapenems for treatment of infections which carries its own risk of furthering resistance. [PMID:25234380] The genes are named with the prefix "bla", which stands for "beta-lactam", followed by the enzyme, for example, blaCTX-M-1. Source: Regenstrief LOINC

Fully-Specified Name

Bacterial beta-lactam resistance ESBL blaCTX-M-8+blaCTX-M-25 group genes

Additional Names

Short Name
blaCTX-M-8+blaCTX-M-25 Gr Islt/Spm Ql
Display Name
Beta-lactam resistance ESBL blaCTX-M-8+blaCTX-M-25 Group genes Molgen Ql (Islt/Spec)
Consumer Name Alpha
Beta-lactam Resistance ESBL blaCTX-M-8+blaCTX-M-25 Group genes

Example Answer List LL360-9

Source: Regenstrief Institute

Answer Code Score Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Basic Attributes

First Released
Version 2.61
Last Updated
Version 2.67
Change Reason
Updated System from "Isolate" and Method from "Probe.amp.tar" according to the new, more sustainable model for LOINC molecular resistance terms [Approved by LOINC Laboratory Committee in June 2018].
Order vs. Observation

Member of these Panels

LOINC Long Common Name
93698-9 Gram negative bacterial resistance panel by Molecular genetics method

Language Variants Get Info

zh-CNChinese (China)
细菌 beta-内酰胺耐药 ESBL blaCTX-M-8+blaCTX-M-25 组基因:存在情况或阈值:时间点:分离株/标本:序数型:分子遗传学类实验室方法
nl-NLDutch (Netherlands)
bacteriële bètalactamresistentie ESBL blaCTX-M-8 + blaCTX-M-25 groep genen:aanwezigheid:moment:isolaat of monster:ordinaal:moleculair genetisch onderzoek
fr-FRFrench (France)
Résistance bactérienne aux bêta lactamases ESBL blaCTX-M-8+blaCTX-M-25 groupe gène:Présence/Seuil:Ponctuel:Isolat/échantillon:Qualitatif:Biologie moléculaire
de-DEGerman (Germany)
Bakterielle Beta-Lactam-Resistenz ESBL blaCTX-M-8+blaCTX-M-25-Gruppen-Gene:Nachweis oder Schwellenwert:Zeitpunkt:Isolat oder Probenmaterial:Ordinal:Molekulargenetisch
it-ITItalian (Italy)
Resistenza batterica beta-lactamica, geni Gruppo ESBL blaCTX-M-8+blaCTX-M-25:PrThr:Pt:Isolato/Campione:Ord:Molgen
es-MXSpanish (Mexico)
Resistencia bacteriana a betalactámicos BLEE blaCTX-M-8 + blaCTX-M-25 Genes del grupo:Presencia o umbral:Punto temporal:Aislado o espécimen:Ordinal:Genética molecular
es-ESSpanish (Spain)
Grupo genes bacterianos ESBL blaCTX-M-8+blaCTX-M-25 resistente a beta-lactámicos:PrThr:Punto temporal:Muestra aislada:Ord:Genética molecular

LOINC FHIR® API Example - CodeSystem Request Get Info