Version 2.73

86199-7Rotavirus A Ag [Presence] in Tissue by Immune stainActive

Part Description

LP204843-9   Rotavirus A
Rotaviruses are non-enveloped, multilayered, icosahedral viruses composed of an outer layer, an inner layer, and a core. After the immature, double-layered virus is assembled in the host cell cytoplasm, they bud across the endoplasmic reticulum (ER) and acquire a temporary membrane that has on its surface the ER resident viral glycoproteins NSP4, VP4 and VP7. The virus loses its temporary membrane and the NSP4 glycoprotein as it moves toward the center of the ER cisternae. The VP4 and VP7 proteins are pushed to the outermost membrane layer and become the mature triple-layered rotavirus. The outer capsid glycoprotein VP7 is believed to be important for the attachment to and entry in the host cell. After it enters the host cell, the VP7 glycoprotein is lost. [UniProt:Q89865] When the host cell lyses, the mature virus are released. There are eight groups of rotavirus, A through H. Groups A, B, C, and H are associated with an acute gastroenteritis and are found in humans and animals. Groups D, E, F, and G are found only in animals. Rotavirus A (RVA) are the cause an acute gastroenteritis in children and animals. RVA is the most common infectious organism to cause severe gastroenteritis in children less than 3 years of age. It is estimated that 95% of children worldwide between the ages of 3 and 5 will become infected with RVA. Approximately 8000 children under 5 years of age in Latin America and the Caribbean die of acute enteritis caused by RVA. [PMID:2556635][http://www.sciencedirect.com/science/article/pii/S004268220700400X?via%3Dihub][PMID:27462899] Source: Regenstrief LOINC, A blood group

Fully-Specified Name

Rotavirus A Ag
Immune stain

Additional Names

Short Name
RVA Ag Tiss Ql ImStn
Display Name
Rotavirus A Ag Immune stain Ql (Tiss)
Consumer Name Alpha
Rotavirus A antigen, Tissue

Example Answer List LL360-9

Source: Regenstrief Institute

Answer Code Score Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Basic Attributes

First Released
Version 2.61
Last Updated
Version 2.64
Change Reason
Updated System from "Tissue" to "Tiss" to be consistent with other laboratory tissue terms.; Abbreviated "Rotavirus A" to "RVA" in the Shortname for consistency across terms.
Order vs. Observation

Language Variants Get Info

zh-CNChinese (China)
轮状病毒 A 组 抗原:存在情况或阈值:时间点:组织与涂片:序数型:免疫染色法
nl-NLDutch (Netherlands)
Rotavirus A Ag:aanwezigheid:moment:weefsel en uitstrijkjes:ordinaal:immunokleuring
fr-FRFrench (France)
Rotavirus A Ag:Présence/Seuil:Ponctuel:Tissu:Qualitatif:Coloration immune
de-DEGerman (Germany)
Rotavirus A Ag:Nachweis oder Schwellenwert:Zeitpunkt:Gewebe:Ordinal:Immunfärbung
it-ITItalian (Italy)
Rotavirus A , Ag:PrThr:Pt:Tessuto:Ord:Colorazione immunologica
es-MXSpanish (Mexico)
Rotavirus A Ag:Presencia o umbral:Punto temporal:Tejido y frotis:Ordinal:Mancha inmune
es-ESSpanish (Spain)
Rotavirus A Antígeno:PrThr:Punto temporal:Tejido:Ord:Tinción de inmunohistoquímica

LOINC FHIR® API Example - CodeSystem Request Get Info