Version 2.73

86202-9Porcine epidemic diarrhea virus [Presence] in Tissue by Immune stainActive

Term Description

Sample types for this test include formalin-fixed, paraffin-embedded tissue samples, frozen samples, or cell smears/cultures.
Source: Regenstrief LOINC

Part Description

LP182479-8   Porcine epidemic diarrhea virus
Porcine Epidemic Diarrhea Virus (PEDv) is a large-enveloped RNA virus, which is a member of the genus Alphacoronavirus within the Coronaviridae family. The complete PEDv genome consists of 5 gene segments: open reading frame 1 (ORF1), spike (S), envelope (E), membrane (M), and nucleocapsid (N). It is encapsulated by a single N protein. The S protein contributes to the stimulation of neutralizing antibodies in the infected host. Its association to adapted growth in vitro and attenuation in vivo lends itself to use for genetic comparison among PEDV isolates and effective vaccines. The M protein is required for assembly and can also induce the production of virus-neutralizing antibodies. The E protein contributes to coronavirus budding. The N protein has functions associated with viral replication and pathogenesis.
PEDv causes viral enteritis, which leads to the destruction of villus enterocytes in pigs of all ages. It is spread by the ingestion of feces from infected pigs, resulting in vomiting, watery diarrhea, dehydration, and high mortality, especially in nursery piglets. Disease caused by PEDv is clinically similar to that caused by Transmissible gastroenteritis coronavirus (TGEV) [PMID:26689811]
At least two PEDv strains have been identified in the USA: the US PEDv prototype and S INDEL variant. The INDEL variant PEDv strain has insertions and deletions (INDELs) in the spike (S) gene.[PMID:25279722] The INDEL strain is related to milder clinical signs than prototype strains.[PMID:24750580][PMID:26748596] The genomic differences in the S gene between the US PEDv prototype and INDEL variant may be responsible for the virulence differences. Potential targets when testing for PEDv RNA include the nucleocapsid protein (N) gene and the ~2500 bp fragment of the S-gene. Source: Regenstrief LOINC

Fully-Specified Name

Porcine epidemic diarrhea virus
Immune stain

Additional Names

Short Name
PEDv Tiss Ql ImStn
Display Name
Porcine epidemic diarrhea virus Immune stain Ql (Tiss)
Consumer Name Alpha
Porcine Epidemic Diarrhea virus, Tissue

Example Answer List LL360-9

Source: Regenstrief Institute

Answer Code Score Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Basic Attributes

First Released
Version 2.61
Last Updated
Version 2.63
Change Reason
Updated System from "Tissue" to "Tiss" to be consistent with other laboratory tissue terms.
Order vs. Observation

Language Variants Get Info

zh-CNChinese (China)
nl-NLDutch (Netherlands)
Varkens epidemic diarrhea virus:aanwezigheid:moment:weefsel en uitstrijkjes:ordinaal:immunokleuring
it-ITItalian (Italy)
Virus della diarrea epidemica suina:PrThr:Pt:Tessuto:Ord:Colorazione immunologica
ru-RURussian (Russian Federation)
Свиная эпидемическая диаррея вирус:PrThr:ТчкВрм:Тк:Пор:Иммуногистохимическая окраска
es-MXSpanish (Mexico)
Virus de la diarrea epidémica porcina:Presencia o umbral:Punto temporal:Tejido y frotis:Ordinal:Mancha inmune
es-ESSpanish (Spain)
Virus de la diarrea epidémica porcina:PrThr:Punto temporal:Tejido:Ord:Tinción de inmunohistoquímica
tr-TRTurkish (Turkey)
Porsin epidemik diyare virüsü:MevcEşik:Zmlı:Doku:Srl:İmmün boyama

LOINC FHIR® API Example - CodeSystem Request Get Info