LOINC
Version 2.67

87321-6Escherichia coli enterotoxigenic sta gene [Presence] in Isolate by NAA with probe detectionActive

Part Description

LP262495-7   Escherichia coli enterotoxigenic sta gene
Enterotoxigenic Escherichia coli (ETEC) produces a heat-labile (LT) and a heat-stable (ST) enterotoxin, both of which cause severe diarrhea in both humans and animals. ST is an extracellular toxin which is comprised of a methanol-soluble (STa) toxin and a methanol-insoluble (STb) toxin. The sta gene encodes the STa toxin and the stb gene encodes the STb toxin. [UniProt: Q70Q79]; [UniProt: Q70Q73] STa combines to its enterocyte receptor, guanylate cyclase, which causes intestinal secretion and diarrhea. [PMID: 8528070] The STb enterocyte receptor is the protein sulfatide. After STb binds to sulfatide, it is engulfed by the enterocyte. It then activates the pertussis toxin-sensitive G protein which opens the ligand-gated calcium ion channel, allowing an influx of calcium ions. A subsequent secretion of chloride ions, stimulation of arachidonic acid release, and production of prostaglandin E2 and 5-dyroxytryptamine leads to an efflux of water, bicarbonate ions, sodium ions, and chloride ions into the intestinal space, all of which leads to watery diarrhea. [PMID: 23716609] Source: Regenstrief LOINC

Fully-Specified Name

Component
Escherichia coli enterotoxigenic sta gene
Property
PrThr
Time
Pt
System
Isolate
Scale
Ord
Method
Probe.amp.tar

Additional Names

Short Name
ETEC sta gene Islt Ql NAA+probe
Display Name
E. coli enterotoxigenic sta gene NAA+probe Ql (Isol)

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.63
Last Updated
Version 2.63
Order vs. Observation
Both

Example Answer List LL360-9

Source: Regenstrief Institute

Answer Code Score Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Member of these Panels

LOINC Long Common Name
88125-0 Escherichia coli enterotoxigenic gene panel - Unspecified specimen by NAA with probe detection

Language Variants Get Info

zh-CNChinese (CHINA)
大肠埃希菌肠产毒素型 sta 基因:存在情况或阈值:时间点:分离株:序数型:探针法.基因扩增.靶向
fr-FRFrench (FRANCE)
Escherichia coli entérotoxinogène sta gène:Présence/Seuil:Ponctuel:Isolat:Qualitatif:PCR amplification de cible
it-ITItalian (ITALY)
Escherichia coli enterotossigeni gene sta:PrThr:Pt:Isolato:Ord:Sonda.amp.tar
es-ESSpanish (SPAIN)
Gen sta Escherichia coli enterotoxigenico:PrThr:Punto temporal:Aislado:Ord:Sonda con amplificación dirigida

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=87321-6