LOINC
Version 2.73

87715-9Influenza virus A HA gene [Nucleotide sequence] in Isolate by SequencingActive

Part Descriptions

LP263480-8   Influenza virus A HA gene
The influenza A virus (FLUAV) is a common respiratory virus that infects humans as well as birds, horses, seals, dogs, and pigs. There are eight gene segments that make up the negative single-stranded RNA of the FLUAV. The gene segments are known as PB1, PB2, PA, NP, HA, NA, M, and NS. Hemagglutinin (HA) and neuraminidase (NA) have high antigenic variation and are the two glycoproteins on the FLUAV surface that designate its subtype. The subtypes of FLUAV that are currently found within the human population are H1N1 and H3N2. HA and NA subtypes are preserved in the avian species and comprise the pool of virus from which all mammalian FLUAV are drawn. [https://virologyj.biomedcentral.com/articles/10.1186/1743-422X-6-67] Antigenic shift is defined as important antigenic modifications in the HA and/or NA subtype within the human population. Pigs contribute to these antigenic shifts because their trachea contain receptors to both avian and human influenza viruses. The avian and human viruses within the pig trachea replicate in close proximity to one another, and are able to exchange genetic material and thereby create new strains of virus.[http://www.clinlabnavigator.com/influenza-virus-subtypes.html] Source: Regenstrief LOINC

LP150045-5   Sequencing
Sequencing is a method used to determine the sequence of individual genes, larger genetic regions (i.e. clusters of genes or operons), full chromosomes or entire genomes. Historically, most sequencing has been performed using the chain termination method developed by Frederick Sanger in 1977.[PMID:271968] Sequencing technologies have improved dramatically, making them cheaper, faster, and more accurate. Next-generation sequencing (NGS), also known as high-throughput sequencing, deep sequencing, and second-generation sequencing, is a type of technology that uses parallel sequencing of multiple small fragments of DNA to determine sequence. This "high-throughput" technology has increased the speed and amount of DNA sequenced at a significantly reduced cost.[PMID:18576944] Several NGS platforms (ie, sequencing instruments and associated reagents) have been developed. Third-generation sequencing is another methodology currently under development that uses parallel sequencing similar to NGS. In contrast to NGS, third-generation sequencing uses single DNA molecules rather than amplified DNA as a template.[PMID:20858600] Source: Regenstrief LOINC

Fully-Specified Name

Component
Influenza virus A HA gene
Property
Seq
Time
Pt
System
Isolate
Scale
Nom
Method
Sequencing

Additional Names

Short Name
FLUAV HA gene Islt-Seq
Display Name
FLUAV HA gene sequence Nom (Isol)
Consumer Name Alpha
Influenza A HA gene

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.63
Last Updated
Version 2.64
Order vs. Observation
Both

Member of these Groups

LG32757-3 Influenza virus

Language Variants Get Info

zh-CNChinese (China)
流感病毒 A 型血凝素基因:序列:时间点:分离株:名义型:序列测定
nl-NLDutch (Netherlands)
Influenzavirus A HA-gen:nucleotidevolgorde:moment:isolaat:nominaal:sequencing
fr-FRFrench (France)
Influenza virus A gène HA:Séquence nucléotidique:Ponctuel:Isolat:Résultat nominal:Séquençage
de-DEGerman (Germany)
Influenza-Virus A HA-Gen:Sequenz:Zeitpunkt:Isolat:Nominal:Sequenzierung
it-ITItalian (Italy)
Influenza virus A HA, gene:Seq:Pt:Isolato:Nom:Sequenziamento
es-MXSpanish (Mexico)
Gen HA del virus de la influenza A:Secuencia de nucleótidos:Punto temporal:Aislado:Nominal:Secuenciación
es-ESSpanish (Spain)
Gen A HA virus Influenza:Secuencia de nucleótidos:Punto temporal:Aislado:Nom:Secuenciación

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https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=87715-9