Version 2.72

87755-5Clostridioides difficile BI-NAP1-027 strain DNA [Presence] in Stool by NAA with probe detectionActive

Part Description

LP263522-7   Clostridioides difficile BI-NAP1-027 strain
Clostridium difficile (CD) infections in hospitals across the United States, Canada and Europe experienced an enormous increase between 2000 and 2006. The pathogen that was found to cause this outbreak was the strain of CD determined by restriction endonuclease analysis (REA) to be toxin type III, restriction endonuclease analysis (REA) group B1; by pulsed-field gel electrophoresis as North American pulsed-field type NAP1; and by polymerase chain reaction (PCR) ribotyping as type 027. The strain is identified as Clostridium difficile BI/NAP1/027 or NAP1. The NAP1 strain of CD produces increased levels of three toxins, the usual toxins A and B, and a binary toxin. A mutation of the toxin A and B suppressor gene tcdC may explain the increased production of toxin. It is also strongly resistant to treatment with fluoroquinolone antibiotics. CD NAP1 is not a new strain of CD. It was isolated between 1984 and 1992 and is identical to the strain isolated is the 2000s, except that the original CD NAP1 strain was not resistant to the new fluoroquinolone drugs of the time, which included gatifloxacin and moxifloxacin. Risk factors for infection with CD NAP1 include advanced age, hospitalization, and exposure to antibiotics, notably fluoroquinolones and cephalosporins. The elderly are especially vulnerable to infection, and have a 30-day mortality rate of more than 5%.[PMID:19457419] Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Regenstrief LOINC, Clostridium difficile (Wikipedia)

Fully-Specified Name

Clostridioides difficile BI-NAP1-027 strain DNA

Additional Names

Short Name
C diff BI NAP1 027 DNA Stl Ql NAA+probe
Display Name
C. difficile BI-NAP1-027 strain DNA NAA+probe Ql (Stl)
Consumer Name Alpha
Clostridioides difficile BI-NAP1-027 strain, Stool

Example Answer List LL744-4

Source: Regenstrief Institute

Answer Code Score Answer ID
Detected LA11882-0
Not detected LA11883-8

Basic Attributes

First Released
Version 2.63
Last Updated
Version 2.66
Change Reason
Updated genus name from Clostridium to Clostridioides based on current (2019) accepted nomenclature for this genus [PMID:27370902].
Order vs. Observation

Member of these Panels

LOINC Long Common Name
95183-0 Clostridioides difficile toxin and BI-NAP1-027 strain DNA panel - Stool by NAA with probe detection

Language Variants Get Info

zh-CNChinese (China)
艰难梭菌 BI-NAP1-027 株 DNA:存在情况或阈值:时间点:大便:序数型:探针法.基因扩增.靶向
fr-FRFrench (France)
Clostridioides difficile souche BI-NAP1-027 ADN:Présence/Seuil:Ponctuel:Selles:Qualitatif:PCR amplification de cible
it-ITItalian (Italy)
Clostridium difficile BI-NAP1-027, variante DNA:PrThr:Pt:Feci:Ord:Sonda.amp.tar
es-MXSpanish (Mexico)
ADN de la cepa de Clostridioides difficile BI-NAP1-027:Presencia o umbral:Punto temporal:Heces:Ordinal:Amplificación de ácidos nucleicos con detección de sonda
es-ESSpanish (Spain)
Cepa BI-NAP1-027 Clostridium difficile ADN:PrThr:Punto temporal:Heces:Ord:Sonda con amplificación dirigida

LOINC FHIR® API Example - CodeSystem Request Get Info