LOINC
Version 2.72

88303-3Lambda light chains [Presence] in 24 hour Urine by ImmunofixationActive

Part Descriptions

LP15031-5   Immunoglobulin light chains.lambda
All immunoglobulins contain two polypeptide chains: a long (heavy) and a short (light) chain. The two chains interact via disulfide bonds. There are two types of light chains, named kappa and lambda. Serum free light chain (SFLC) testing, a kappa/lambda ratio and a protein electrophoresis test are done to help detect, diagnose and monitor plasma cell disorders (dyscrasias) including multiple myeloma and primary amyloidosis. Normal readings are seen when there is a kappa/lambda ratio of approximately 0.26 to 1.65 and free light chains are present in the blood at low levels. Increased kappa free light chains and an increased kappa/lambda ratio are present with plasma cell disorders that produce excess monoclonal kappa light chains. The tests can also be used to monitor response to treatment. An increase in serum free light chains along with an abnormal kappa/lambda ratio may indicate primary amyloidosis; biopsy of affected tissue is typically used for confirmation of diagnosis. [PMID:6802926] [Lab Tests Online:free-light/tab/test] Source: Regenstrief LOINC

LP6336-4   Immunofixation
Plasma or concentrated urine is deposited on a gel. With an electrical current the proteins are sorted in function of their size, after which antigens for each targeted type of immunoglobulin are deposited on the gel. Thus more or less narrow bands appear on the gel, marking the location of the various immunoglobulines.
Immunofixation tends to replace protein electrophoresis because:

• it is faster (results within three hours);
• it is somewhat more sensitive. Immunofixation may reveal an immunoglobulin missed out by protein electrophoresis, especially at low concentrations (less than 1 gram/litre);
• it can be partially automated and can be used in more laboratories;
• it is more easily read and interpreted.

Immunofixation is however only sensitive to immunoglobulins and is more expensive than protein electrophoresis. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Immunofixation

Fully-Specified Name

Component
Immunoglobulin light chains.lambda
Property
PrThr
Time
24H
System
Urine
Scale
Ord
Method
Immunofixation

Additional Names

Short Name
Lambda LC 24h Ur Ql IFE
Display Name
Immunoglobulin light chains.lambda Immunofixation Ql (24H U)
Consumer Name Alpha
Immunoglobulin light chains.lambda, Urine

Example Answer List LL744-4

Source: Regenstrief Institute

Answer Code Score Answer ID
Detected LA11882-0
Not detected LA11883-8

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.64
Last Updated
Version 2.64
Order vs. Observation
Both

Member of these Groups

LG17766-3 Immunoglobulin light chains.lambda|PrThr|24H|ANYUrine
LG36222-4 Immunoglobulin light chains.lambda|PrThr|Urine

Language Variants Get Info

zh-CNChinese (China)
免疫球蛋白轻链.Lambda 型:存在情况或阈值:24小时:尿液:序数型:免疫固定电泳分析法
nl-NLDutch (Netherlands)
immunoglobuline lichte ketens.lambda:aanwezigheid:24 uur:urine:ordinaal:immunofixatie
et-EEEstonian (Estonia)
Immuunoglobuliini kerged ahelad.lambda:PrThr:24 tunni:U:Ord:Immuunfiksatsioon
fr-BEFrench (Belgium)
Chaînes légères immunoglobulines.lambda:PrThr:24 h:Urine:Ordinal:Immunofixation
fr-CAFrench (Canada)
Chaînes légères d'immunoglobulines.lambda:Présence-Seuil:24 h:Urine:Ordinal:Immunofixation
fr-FRFrench (France)
Immunoglobuline chaines légères lambda:Présence/Seuil:24H:Urine:Qualitatif:Immunofixation
it-ITItalian (Italy)
Immunoglobuline, catene leggere.lambda:PrThr:24h:Urine:Ord:Immunofissazione
ru-RURussian (Russian Federation)
Иммуноглобулин легкие цепи.лямбда:PrThr:24 часа:Моча:Пор:Иммунофиксация
es-MXSpanish (Mexico)
Cadenas ligeras de inmunoglobulina lambda:Presencia o umbral:24H:Orina:Ordinal:Inmunofijación
es-ESSpanish (Spain)
Cadenas ligeras de las inmunoglobulinas.lambda:PrThr:24 horas:Orina:Ord:Inmunofijación
tr-TRTurkish (Turkey)
İmmünglobulin hafif zincirler.lambda:MevcEşik:24Sa:İdrar:Srl:İmmünfiksasyon

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=88303-3