88558-2Cytomegalovirus DNA [Presence] in Lower respiratory specimen by NAA with probe detectionActive
Part Description
LP14255-1 Cytomegalovirus
Cytomegalovirus is a member of the family Herpesviridae and also known as Human Herpesvirus-5 (HHV-5). It contains a linear double-stranded DNA encased in an icosahedral capsid that is surrounded by a viral envelope. It replicates slowly and may take weeks for the infection to become visible microscopically. Its life cycle includes a lytic and a latent phase. During the lytic phase the cytoskeleton of the infected cell is disrupted and becomes very large. The enlarged cell eludes detection by natural killer (NK) cells by encoding UL16. UL16 is a protein that binds to the ligand NDG2D which is a surface receptor on NK cells and, when blocked, prevents the CMV infected cell from apoptotic signaling to NK cells to destroy it.[https://pedclerk.bsd.uchicago.edu/page/cytomegalovirus-cmv] In the US one in three children are infected by CMV by the age of five and over half of adults are infected by age 40. Infection with CMV is mostly asymptomatic. Symptoms when present include fever, sore throat, fatigue, swollen glands. CMV can occasionally lead to mononucleosis or hepatitis. Immunocompromised patients experience much more acute symptoms that can affect the eyes, lungs, liver, esophagus, stomach, and intestines. For babies born with CMV, involvement with the brain, spleen, lung, liver can occur. In addition, there may be growth problems and hearing loss which is the most common symptom in congenital CMV infection. CMV is transmitted in urine, saliva, blood, tears, semen and breast milk by direct contact. Normally no treatment is necessary, but for severe cases medication is available.[https://www.cdc.gov/cmv/overview.html]
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- Cytomegalovirus DNA
- Property
- PrThr
- Time
- Pt
- System
- Respiratory.lower
- Scale
- Ord
- Method
- Probe.amp.tar
Additional Names
- Short Name
- CMV DNA Lower resp Ql NAA+probe
- Display Name
- CMV DNA NAA+probe Ql (Lower resp)
- Consumer Name Alpha
- Cytomegalovirus (CMV), Lower respiratory
Example Answer List LL744-4
Source: Regenstrief Institute
| Answer | Code | Score | Answer ID |
|---|---|---|---|
| Detected | LA11882-0 | ||
| Not detected | LA11883-8 |
Basic Attributes
- Class
- MICRO
- Type
- Laboratory
- First Released
- Version 2.64
- Last Updated
- Version 2.64
- Order vs. Observation
- Both
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 94393-6 | Respiratory pathogens DNA and RNA panel - Lower respiratory specimen by NAA with probe detection |
Member of these Groups
| LG34031-1 | Cytomegalovirus DNA| |
Language Variants Get Info
- zh-CNChinese (China)
- 巨细胞病毒 DNA:
存在情况或阈值: 时间点: 呼吸道.下: 序数型: 探针法.基因扩增.靶向 - nl-NLDutch (Netherlands)
- Cytomegalovirus DNA:
aanwezigheid: moment: onderste luchtwegen: ordinaal: moleculaire techniek (PCR) - fr-CAFrench (Canada)
- Cytomégalovirus , ADN:
Présence-Seuil: Temps ponctuel: Système respiratoire.inférieur: Ordinal: Sonde avec amplification de la cible - fr-FRFrench (France)
- Cytomégalovirus ADN:
Présence/Seuil: Ponctuel: Voies respiratoires inférieures: Qualitatif: PCR amplification de cible - it-ITItalian (Italy)
- Citomegalovirus DNA:
PrThr: Pt: Sistema respiratorio.inferiore: Ord: Sonda.amp.tar - es-MXSpanish (Mexico)
- ADN de citomegalovirus:
Presencia o umbral: Punto temporal: Muestra de vías respiratorias inferiores: Ordinal: Amplificación de ácidos nucleicos con detección de sonda - es-ESSpanish (Spain)
- Citomegalovirus ADN:
PrThr: Punto temporal: Tracto respiratorio inferior: Ord: Sonda con amplificación dirigida - tr-TRTurkish (Turkey)
- Cytomegalovirus DNA:
MevcEşik: Zmlı: Respiratuvar.alt: Srl: Prob.amf.hdf
LOINC FHIR® API Example - CodeSystem Request Get Info
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=88558-2
LOINC Copyright
Copyright © 2022 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright