LOINC
Version 2.72

88904-8Influenza virus A Ag [Presence] in Lower respiratory specimen by ImmunofluorescenceActive

Term Description

Samples that are positive for influenza virus display fluorescence in the cytoplasmic and/or nucleus. Cytoplasmic staining appears punctate with large inclusions, and nuclear staining is typically uniformly bright.
Source: Regenstrief LOINC

Part Description

LP14239-5   Influenza virus A
Influenza viruses, from the family Orthomyxoviridae, are enveloped negative-strand RNA viruses with segmented genomes containing seven to eight gene segments. Of the five genera in the family, only influenza A virus (IAV), influenza B and C are medically relevant to humans. Aquatic birds harboring avian IAV are the likely natural reservoir for all known IAV subtypes and are probably the original source of all human pandemic IAV strains. IAV maintained in wild birds have been associated with stable host switch events to novel hosts, including most often to domestic poultry but also to horses, swine, toothed whales and humans. The influenza virus life cycle begins with the binding of viral HA to host cell receptors. Endocytosis and HA-mediated fusion of the viral and cellular membranes occurs. Viral ribonucleoprotein complexes are released into the cytoplasm, travel to the nucleus, then are replicated and transcribed by the viral polymerase complex. The new viruses are formed and bud when the newly formed ribonucleicprotein complexes and structural proteins reach the plasma membrane. Further research is needed to better understand how IAVs switch hosts and the viral genetic changes that underlie human adaptation. IAV causes respiratory infections in humans ranging from asymptomatic to fatal. Pandemics are attributed to "novel" viruses which possess a viral hemagglutinin (HA) to which humans do not have immunity. [PMID:20542248] [PMID:25812763]
Influenza viruses A and B are single-stranded RNA enveloped viruses belonging to the Orthomyxoviridae family. The symptoms of infection of Influenza A and B include fever, cough, sore throat, rhinorrhea, nasal congestion, headache, myalgia and malaise. Some patients may experience gastrointestinal symptoms including watery diarrhea, vomiting and abdominal pain. The influenza viruses spread rapidly in enclosed spaces with a documented rate of infection of 70% following a common source of exposure. Infection occurs in the respiratory epithelium in both the upper and lower respiratory tract, and the virus can be found in many specimen types, including nasal aspirates, nasal or nasopharyngeal swabs, throat swabs, sputum and tracheal aspirates. When infection rates reach epidemic proportions, hospitalization of children and elderly patients rises as does the mortality rates of elderly patients.(Manual of Clinical Microbiology, 11th edition, James H. Jorgensen; Karen C. Carroll; Guido Funke; Michael A Pfaller; Marie Louise Landry; Sandra S. Richter; David W. Warnock) Source: Regenstrief LOINC

Fully-Specified Name

Component
Influenza virus A Ag
Property
PrThr
Time
Pt
System
Respiratory.lower
Scale
Ord
Method
IF

Additional Names

Short Name
FLUAV Ag Lower resp Ql IF
Display Name
FLUAV Ag IF Ql (Lower resp)
Consumer Name Alpha
Influenza A (Flu A) antigen, Lower respiratory

Example Answer List LL744-4

Source: Regenstrief Institute

Answer Code Score Answer ID
Detected LA11882-0
Not detected LA11883-8

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.64
Last Updated
Version 2.64
Order vs. Observation
Both

Member of these Groups

LG32757-3 Influenza virus
LG34020-4 Influenza virus A Ag|PrThr|Sys:ANYResp

Language Variants Get Info

zh-CNChinese (China)
流感病毒 A 型 抗原:存在情况或阈值:时间点:呼吸道.下:序数型:免疫荧光法
nl-NLDutch (Netherlands)
Influenzavirus A Ag:aanwezigheid:moment:onderste luchtwegen:ordinaal:immunofluorescentie
fr-CAFrench (Canada)
Virus de l'influenza A , Ag:Présence-Seuil:Temps ponctuel:Système respiratoire.inférieur:Ordinal:Immunofluorescence
fr-FRFrench (France)
Influenza virus A Ag:Présence/Seuil:Ponctuel:Voies respiratoires inférieures:Qualitatif:Immunofluorescence
it-ITItalian (Italy)
Influenza A, virus , Ag:PrThr:Pt:Sistema respiratorio.inferiore:Ord:IF
es-MXSpanish (Mexico)
Virus de la influenza A Ag:Presencia o umbral:Punto temporal:Muestra de vías respiratorias inferiores:Ordinal:Inmunofluorescencia (IF)
es-ESSpanish (Spain)
Virus Influenza A Antígeno:PrThr:Punto temporal:Tracto respiratorio inferior:Ord:Inmunofluorescencia (IF)
tr-TRTurkish (Turkey)
İnfluenza virüsü A Ag:MevcEşik:Zmlı:Respiratuvar.alt:Srl:IF

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=88904-8