Version 2.72

88926-1Histoplasma capsulatum DNA [Presence] in Tissue by NAA with probe detectionActive

Part Description

LP16650-1   Histoplasma capsulatum
Histoplasmosis capsulatum is a dimorphic fungal pathogen with filamentous or yeast forms,depending on nutritional factors and temperature.The M antigen is a well-known glycoprotein used as a diagnostic antigen for acute histoplasmosis as it induces the first precipitins during disease. Monoclonal antibodies (mAbs) to the M antigen have been found to modify the pathogenesis of histoplasmosis.Given the shortcomings of current therapies, the administration of mAbs is being investigated. [PMID:22347215] The H band is less commonly seen than the M band and is indicative of chronic or severe acute infections with H capsulatum.

H. capsulatum is found in nature primarily as a saprophytic mold. The mold form is comprised of hyaline septate hyphae, which produce two different asexual reproduction structures, macroconidia and microconidia. The micronidia are believed to be responsible for disease propagation since their 2-6 µm size is well suited for disposition into the distal alveoli. Infection is typically acquired through inhalation of fungal propagules upon disturbances of contaminated soil or excreta. Environmental and genetic factors influence disease manifestations which can range from asymptomatic or mild influenza-like disease to a disseminated sepsis form. Manifestations depend on the magnitude of exposure, the host's immunological status and the virulence of the infective strain. Reactivation of latent infection can result in significant disease, particularly for immunosuppressed individuals. Despite the availability of potent antifungal drugs, nearly one in ten patients hospitalized with histoplasmosis dies.[PMID:17223625] Source: Regenstrief LOINC

Fully-Specified Name

Histoplasma capsulatum DNA

Additional Names

Short Name
H capsul DNA Tiss Ql NAA+probe
Display Name
H. capsulatum DNA NAA+probe Ql (Tiss)
Consumer Name Alpha
Histoplasma capsulatum, Tissue

Example Answer List LL744-4

Source: Regenstrief Institute

Answer Code Score Answer ID
Detected LA11882-0
Not detected LA11883-8

Basic Attributes

First Released
Version 2.64
Last Updated
Version 2.64
Order vs. Observation

Member of these Panels

LOINC Long Common Name
95918-9 Fungal pathogens panel - Tissue by NAA with probe detection

Language Variants Get Info

zh-CNChinese (China)
荚膜组织胞浆菌 DNA:存在情况或阈值:时间点:组织与涂片:序数型:探针法.基因扩增.靶向
nl-NLDutch (Netherlands)
Histoplasma capsulatum DNA:aanwezigheid:moment:weefsel en uitstrijkjes:ordinaal:moleculaire techniek (PCR)
fr-BEFrench (Belgium)
Histoplasma capsulatum ADN:PrThr:Temps ponctuel:Tissu:Ordinal:Sonde avec amplification de la cible
fr-CAFrench (Canada)
Histoplasma capsulatum , ADN:Présence-Seuil:Temps ponctuel:Tissu:Ordinal:Sonde avec amplification de la cible
fr-FRFrench (France)
Histoplasma capsulatum ADN:Présence/Seuil:Ponctuel:Tissu:Qualitatif:PCR amplification de cible
it-ITItalian (Italy)
Histoplasma capsulatum DNA:PrThr:Pt:Tessuto:Ord:Sonda.amp.tar
ru-RURussian (Russian Federation)
Histoplasma capsulatum ДНК:PrThr:ТчкВрм:Тк:Пор:Проба.усил.миш
es-MXSpanish (Mexico)
ADN de Histoplasma capsulatum:Presencia o umbral:Punto temporal:Tejido y frotis:Ordinal:Amplificación de ácidos nucleicos con detección de sonda
es-ESSpanish (Spain)
Histoplasma capsulatum ADN:PrThr:Punto temporal:Tejido:Ord:Sonda con amplificación dirigida
tr-TRTurkish (Turkey)
Histoplazma Kapsulatum DNA:MevcEşik:Zmlı:Doku:Srl:Prob.amf.hdf

LOINC FHIR® API Example - CodeSystem Request Get Info