Version 2.74

Part Description

LP221384-3   Zika virus non-structural protein 1
The Zika virus (ZIKV) nonstructural protein 1 (NS1) is secreted by infected cells and is involved in immune evasion and pathogenesis. While there is some structural similarity between ZIKV NS1 and NS1 from other flaviviruses, antibodies to ZIKV NS1 have been found to be relatively ZIKV-specific. [PMID: 27417494]
Zika virus (ZIKV) is a flavivirus transmitted primarily by the Aedes mosquito which was first identified in a sentinel monkey in the Zika forest in Uganda in 1947. Since 2014 it has spread explosively in the Americas where it has infected hundreds of thousands of people. About 80% of those infected are asymptomatic. Common symptoms include fever, headache, rash, arthralgia and conjunctivitis. Since the end of 2015, there has been an increase in ZIKV-associated cases of Guillain-Barre syndrome and a tremendous increase in cases of microcephaly in fetuses and newborns in Brazil, raising worldwide public health concern. Recent predictions are that the mosquito species A. Albopictus, which can hibernate and survive cool temperatures, will carry ZIKV to more temperate areas of North America, Australia and Southern Europe. It is still not clear whether ZIKV in humans increases viral titers enough to trigger a new cycle when an infected person is bitten by a naïve mosquito. Direct human-to-human transmission has been documented to occur perinatally, sexually (primarily through semen), through breastfeeding, blood transfusion and through occupational transmission in the laboratory setting. There are currently no specific anti-viral agents, vaccination or medical prophylaxis available. [PMID: 27148186]
ZIKV itself can be detected during the acute phase of infection (4-6 days) using PCR-based methods; alternatively, ZIKV-specific IgM antibodies or a significant titer increase of ZIKV-specific IgG is proof of acute infection. Antibody titers should be performed using serum samples from the acute and convalescent stages with at least 2 weeks between blood draws. Source: Regenstrief LOINC, PMID: 27417494

Fully-Specified Name

Component
Zika virus non-structural protein 1 Ab.IgM
Property
ACnc
Time
Pt
System
Ser/Plas
Scale
Qn
Method
IA

Additional Names

Short Name
ZIKV NS1 IgM SerPl IA-aCnc
Display Name
ZIKV non-structural protein 1 IgM IA Qn
Consumer Name Alpha
Zika virus non-structural protein 1 IgM antibody, Blood

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.64
Last Updated
Version 2.65
Change Reason
Updated the System from Ser to Ser/Plas since this test can be performed on plasma specimens as well.
Order vs. Observation
Both

Member of these Panels

LOINC Long Common Name
89368-5 Zika virus non-structural protein 1 IgM panel - Serum or Plasma by Immunoassay

Member of these Groups

LOINC Group Group Name
LG32774-8 Zika virus

Language Variants

Tag Language Translation
zh-CN Chinese (China) 寨卡病毒非结构蛋白 1 抗体.IgM:任意型浓度:时间点:血清/血浆:定量型:免疫测定法
Synonyms: Ⅰ Ab.IgM;IgM;抗体 IgM Ab;自身抗体 I PR;Prot;成分 - 化学 - 蛋白质类;蛋白;朊;蛋白质类;蛋白质类物质 任意型浓度(单位体积);任意浓度;单位体积的任意单位数;人工型浓度 传染毒;传染毒素;滤过性病原体;病毒类;过滤性病原体 免疫测定;免疫分析法;免疫检定法;免疫检定;免疫试验;酶免疫测定法;酶免疫测定;酶免疫分析法;酶免疫检定法;酶免疫检定;酶免疫试验 免疫球蛋白 M 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 塞卡病毒;Zika virus;Zika 病毒;ZIKV;济卡病毒;兹卡病毒 寨卡病毒（Zika 病毒、ZIKV、济卡病毒、兹卡病毒、塞卡病毒）非结构蛋白（非结构性蛋白、非结构蛋白质、非结构性蛋白质、NS 蛋白） 1;寨卡病毒 NS1 蛋白 微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体） 时刻;随机;随意;瞬间 血清或血浆
nl-NL Dutch (Netherlands) zikavirus niet-structureel proteïne 1 As.IgM:eenheid/volume:moment:serum of plasma:kwantitatief:immunoassay
Synonyms: antistof; antilichaam IA Zika-virus
es-ES Spanish (Spain) Proteína no estructural del virus del Zica IgM:Concentración arbitraria:Punto temporal:Suero o Plasma:Qn:IA
fr-FR French (France) Zika virus protéine non structurelle 1 Ac IgM:Arbitraire/Volume:Ponctuel:Sérum/Plasma:Numérique:Immunoanalyse
it-IT Italian (Italy) Zika virus, proteina non strutturale 1 Ab.IgM:ACnc:Pt:Siero/Plasma:Qn:IA
Synonyms: Anticorpi IgM anticorpo Concentrazione Arbitraria Immunoassay Microbiologia Plasma Proteina non strutturale 1 del virus Zika Punto nel tempo (episodio) Siero Siero o Plasma Virus Zika
de-DE German (Germany) Zika-Virus Nichtstrukturprotein 1 Ak.IgM:Arbiträre Konzentration:Zeitpunkt:Serum oder Plasma:Quantitativ:Immunoassay
es-MX Spanish (Mexico) Proteína 1 Ab.IgM no estructural del virus del Zika:Concentración arbitraria:Punto temporal:Suero o Plasma:Cuantitativo:Inmunoensayo

Example Units

Unit Source
{EIA_index} Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR®

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=89369-3