Version 2.73

89370-1Zika virus non-structural protein 1 IgM Ab [Interpretation] in Serum by ImmunoassayActive

Term Description

Overall interpretation for Zika virus IgM antibody testing based on an algorithm that considers individual quantitative results for IgG and IgM antibodies to Zika virus antigens. This term was created for, but not limited in use to, the submitter's test kit, Diasorin LIAISON(R) XL Zika Capture IgM. In this assay, the result of the Zika virus IgG antibodies is only used to aid in the interpretation of the IgM result and should not be used individually to determine the patient's Zika IgG status.
Source: Regenstrief LOINC

Part Description

LP221384-3   Zika virus non-structural protein 1
The Zika virus (ZIKV) nonstructural protein 1 (NS1) is secreted by infected cells and is involved in immune evasion and pathogenesis. While there is some structural similarity between ZIKV NS1 and NS1 from other flaviviruses, antibodies to ZIKV NS1 have been found to be relatively ZIKV-specific. [PMID:27417494]
Zika virus (ZIKV) is a flavivirus transmitted primarily by the Aedes mosquito which was first identified in a sentinel monkey in the Zika forest in Uganda in 1947. Since 2014 it has spread explosively in the Americas where it has infected hundreds of thousands of people. About 80% of those infected are asymptomatic. Common symptoms include fever, headache, rash, arthralgia and conjunctivitis. Since the end of 2015, there has been an increase in ZIKV-associated cases of Guillain-Barre syndrome and a tremendous increase in cases of microcephaly in fetuses and newborns in Brazil, raising worldwide public health concern. Recent predictions are that the mosquito species A. Albopictus, which can hibernate and survive cool temperatures, will carry ZIKV to more temperate areas of North America, Australia and Southern Europe. It is still not clear whether ZIKV in humans increases viral titers enough to trigger a new cycle when an infected person is bitten by a naïve mosquito. Direct human-to-human transmission has been documented to occur perinatally, sexually (primarily through semen), through breastfeeding, blood transfusion and through occupational transmission in the laboratory setting. There are currently no specific anti-viral agents, vaccination or medical prophylaxis available. [PMID:27148186]
ZIKV itself can be detected during the acute phase of infection (4-6 days) using PCR-based methods; alternatively, ZIKV-specific IgM antibodies or a significant titer increase of ZIKV-specific IgG is proof of acute infection. Antibody titers should be performed using serum samples from the acute and convalescent stages with at least 2 weeks between blood draws. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Regenstrief LOINC, PMID: 27417494

Fully-Specified Name

Zika virus non-structural protein 1 Ab.IgM

Additional Names

Short Name
Display Name
ZIKV non-structural protein 1 IgM IA (S) [Interp]
Consumer Name Alpha
Zika virus non-structural protein 1 IgM antibody, Blood

Preferred Answer List LL4993-3

Source: Association of Public Health Laboratories

Answer Code Score Answer ID
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6
Presumptive recent Zika negative LA28914-2
Presumptive recent Zika positive LA28915-9
Presumptive Zika IgM positive LA28916-7

Basic Attributes

First Released
Version 2.64
Last Updated
Version 2.64
Order vs. Observation

Member of these Panels

LOINC Long Common Name
89368-5 Zika virus non-structural protein 1 IgM panel - Serum or Plasma by Immunoassay

Member of these Groups

LG32774-8 Zika virus

Language Variants Get Info

zh-CNChinese (China)
寨卡病毒非结构蛋白 1 抗体.IgM:印象:时间点:血清:名义型:免疫测定法
nl-NLDutch (Netherlands)
zikavirus niet-structureel proteïne 1 As.IgM:interpretatie:moment:serum:nominaal:immunoassay
fr-FRFrench (France)
Zika virus protéine non structurelle 1 Ac IgM:Interprétation:Ponctuel:Sérum:Résultat nominal:Immunoanalyse
de-DEGerman (Germany)
Zika-Virus Nichtstrukturprotein 1 Ak.IgM:Interpretation:Zeitpunkt:Serum:Nominal:Immunoassay
it-ITItalian (Italy)
Zika virus, proteina non strutturale 1 Ab.IgM:Imp:Pt:Siero:Nom:IA
es-MXSpanish (Mexico)
Proteína 1 Ab.IgM no estructural del virus del Zika:Impresión / interpretación del estudio:Punto temporal:Suero:Nominal:Inmunoensayo
es-ESSpanish (Spain)
Proteína no estructural del virus del Zica IgM:Impresión/interpretación del estudio:Punto temporal:Suero:Nom:IA

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