Version 2.74

Term Description

Overall interpretation for Zika virus IgM antibody testing based on an algorithm that considers individual quantitative results for IgG and IgM antibodies to Zika virus antigens. This term was created for, but not limited in use to, the submitter's test kit, Diasorin LIAISON(R) XL Zika Capture IgM. In this assay, the result of the Zika virus IgG antibodies is only used to aid in the interpretation of the IgM result and should not be used individually to determine the patient's Zika IgG status.
Source: Regenstrief LOINC

Part Description

LP221384-3   Zika virus non-structural protein 1
The Zika virus (ZIKV) nonstructural protein 1 (NS1) is secreted by infected cells and is involved in immune evasion and pathogenesis. While there is some structural similarity between ZIKV NS1 and NS1 from other flaviviruses, antibodies to ZIKV NS1 have been found to be relatively ZIKV-specific. [PMID: 27417494]
Zika virus (ZIKV) is a flavivirus transmitted primarily by the Aedes mosquito which was first identified in a sentinel monkey in the Zika forest in Uganda in 1947. Since 2014 it has spread explosively in the Americas where it has infected hundreds of thousands of people. About 80% of those infected are asymptomatic. Common symptoms include fever, headache, rash, arthralgia and conjunctivitis. Since the end of 2015, there has been an increase in ZIKV-associated cases of Guillain-Barre syndrome and a tremendous increase in cases of microcephaly in fetuses and newborns in Brazil, raising worldwide public health concern. Recent predictions are that the mosquito species A. Albopictus, which can hibernate and survive cool temperatures, will carry ZIKV to more temperate areas of North America, Australia and Southern Europe. It is still not clear whether ZIKV in humans increases viral titers enough to trigger a new cycle when an infected person is bitten by a naïve mosquito. Direct human-to-human transmission has been documented to occur perinatally, sexually (primarily through semen), through breastfeeding, blood transfusion and through occupational transmission in the laboratory setting. There are currently no specific anti-viral agents, vaccination or medical prophylaxis available. [PMID: 27148186]
ZIKV itself can be detected during the acute phase of infection (4-6 days) using PCR-based methods; alternatively, ZIKV-specific IgM antibodies or a significant titer increase of ZIKV-specific IgG is proof of acute infection. Antibody titers should be performed using serum samples from the acute and convalescent stages with at least 2 weeks between blood draws. Source: Regenstrief LOINC, PMID: 27417494

Fully-Specified Name

Zika virus non-structural protein 1 Ab.IgM

Additional Names

Short Name
Display Name
ZIKV non-structural protein 1 IgM IA (S) [Interp]
Consumer Name Alpha
Zika virus non-structural protein 1 IgM antibody, Blood

Preferred Answer List: LL4993-3

Source: Association of Public Health Laboratories
Answer Code Score Answer ID
NegativeCopyright ID:260385009 Negative (qualifier value) LA6577-6
Presumptive recent Zika negative LA28914-2
Presumptive recent Zika positive LA28915-9
Presumptive Zika IgM positive LA28916-7

Basic Attributes

First Released
Version 2.64
Last Updated
Version 2.64
Order vs. Observation

Member of these Panels

LOINC Long Common Name
89368-5 Zika virus non-structural protein 1 IgM panel - Serum or Plasma by Immunoassay

Member of these Groups

LOINC Group Group Name
LG32774-8 Zika virus

Language Variants

Tag Language Translation
zh-CN Chinese (China) 寨卡病毒非结构蛋白 1 抗体.IgM:印象:时间点:血清:名义型:免疫测定法
Synonyms: Ⅰ Ab.IgM;IgM;抗体 IgM Ab;自身抗体 I PR;Prot;成分 - 化学 - 蛋白质类;蛋白;朊;蛋白质类;蛋白质类物质 传染毒;传染毒素;滤过性病原体;病毒类;过滤性病原体 免疫测定;免疫分析法;免疫检定法;免疫检定;免疫试验;酶免疫测定法;酶免疫测定;酶免疫分析法;酶免疫检定法;酶免疫检定;酶免疫试验 免疫球蛋白 M 分类型应答;分类型结果;名义性;名称型;名词型;名词性;标称性;没有自然次序的名义型或分类型应答 印象是一种诊断陈述,始终是对其他某种观察指标的解释或抽象(一系列检验项目结果、一幅图像或者整个某位病人),而且几乎总是由某位专业人员产生。;检查印象;检查印象/解释;检查的印象/解释;检查解释;解释;阐释 塞卡病毒;Zika virus;Zika 病毒;ZIKV;济卡病毒;兹卡病毒 寨卡病毒(Zika 病毒、ZIKV、济卡病毒、兹卡病毒、塞卡病毒)非结构蛋白(非结构性蛋白、非结构蛋白质、非结构性蛋白质、NS 蛋白) 1;寨卡病毒 NS1 蛋白 微生物学;微生物学试验;微生物学试验(培养、DNA、抗原及抗体) 时刻;随机;随意;瞬间
nl-NL Dutch (Netherlands) zikavirus niet-structureel proteïne 1 As.IgM:interpretatie:moment:serum:nominaal:immunoassay
Synonyms: antistof; antilichaam IA Zika-virus
es-ES Spanish (Spain) Proteína no estructural del virus del Zica IgM:Impresión/interpretación del estudio:Punto temporal:Suero:Nom:IA
fr-FR French (France) Zika virus protéine non structurelle 1 Ac IgM:Interprétation:Ponctuel:Sérum:Résultat nominal:Immunoanalyse
it-IT Italian (Italy) Zika virus, proteina non strutturale 1 Ab.IgM:Imp:Pt:Siero:Nom:IA
Synonyms: Anticorpi IgM anticorpo Immunoassay Impressione/interpretazione di studio Microbiologia Proteina non strutturale 1 del virus Zika Punto nel tempo (episodio) Siero Virus Zika
de-DE German (Germany) Zika-Virus Nichtstrukturprotein 1 Ak.IgM:Interpretation:Zeitpunkt:Serum:Nominal:Immunoassay
es-MX Spanish (Mexico) Proteína 1 Ab.IgM no estructural del virus del Zika:Impresión / interpretación del estudio:Punto temporal:Suero:Nominal:Inmunoensayo

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