LOINC
Version 2.72

89372-7Mycobacterium tuberculosis complex rpoB gene rifAMPin resistance mutation [Presence] by Molecular methodTrial

Status Information

Status
Trial

Part Description

LP267160-2   Mycobacterium tuberculosis complex rpoB gene rifAMPin resistance mutation
Rifampicin (RIF) is a first line drug used to treat Mycobacterium tuberculosis (TB). It inhibits transcription by binding with the rpoB encoded beta-subunit of the DNA-dependent RNA polymerase (RNAP). The majority of the mutations across bacterial species occurs in the 81 bp region of cluster, also known as the rifampicin resistance determining region (RRDR). The RRDR is surrounded by 12 amino acids, 11 of which have been linked to RIF mutations. The mutations in the RRDR usually result in an amino acid substitution that has an associated compact side chain with a larger amino acid and compact side chain. The inflexibility of rifampicin prevents it from being able to bind to the mutated beta subunit of RNAP.[PMID:26038512] Source: Regenstrief LOINC

Fully-Specified Name

Component
Mycobacterium tuberculosis complex rpoB gene rifAMPin resistance mutation
Property
PrThr
Time
Pt
System
Isolate/Specimen
Scale
Ord
Method
Molgen

Additional Names

Short Name
MTB rpoB RIF resist mut Islt/Spm Ql
Display Name
M. tuberculosis complex rpoB gene rifAMPin resistance mutation Molgen Ql (Islt/Spec)
Consumer Name Alpha
Mycobacterium tuberculosis complex rpoB gene rifAMPin resistance mutation

Example Answer List LL744-4

Source: Regenstrief Institute

Answer Code Score Answer ID
Detected LA11882-0
Not detected LA11883-8

Basic Attributes

Class
ABXBACT
Type
Laboratory
First Released
Version 2.64
Last Updated
Version 2.65
Order vs. Observation
Both

Member of these Panels

LOINC Long Common Name
89371-9 MTB complex DNA and rpoB RIF resistance mutation panel [Presence]
89876-7 MTB complex rifAMPin and isoniazid resistance panel by Molecular genetics method

Language Variants Get Info

zh-CNChinese (China)
结核分枝杆菌复合菌群 rpoB 基因利福平耐药性突变:存在情况或阈值:时间点:分离株/标本:序数型:分子遗传学类实验室方法
nl-NLDutch (Netherlands)
Mycobacterium tuberculosis complex rpoB-gen rifampicineresistentie-mutatie:aanwezigheid:moment:isolaat of monster:ordinaal:moleculair genetisch onderzoek
fr-FRFrench (France)
Mycobacterium complexe tuberculosis résistance à la rifampicine rpoB gène mutation:Présence/Seuil:Ponctuel:Isolat/échantillon:Qualitatif:Biologie moléculaire
de-DEGerman (Germany)
Mycobacterium tuberculosis-Komplex rpoB-Gen Rifampicinresistenzmutation:Nachweis oder Schwellenwert:Zeitpunkt:Isolat oder Probenmaterial:Ordinal:Molekulargenetisch
it-ITItalian (Italy)
Mycobacterium tuberculosis complex, gene rpoB rifampina resistente:PrThr:Pt:Isolato/Campione:Ord:Molgen
es-MXSpanish (Mexico)
Mycobacterium tuberculosis complex rpoB gen mutación de resistencia a rifAMPin:Presencia o umbral:Punto temporal:Aislado o espécimen:Ordinal:Genética molecular
es-ESSpanish (Spain)
Mutación Gen rpoB de resistencia a rifampicina de Mycobacterium tuberculosis:PrThr:Punto temporal:Muestra aislada:Ord:Genética molecular

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=89372-7