LOINC
Version 2.72

89508-6Intrinsic factor Ab [Presence] in Serum by Line blotActive

Term Description

This term was created for, but is not limited in use to, the submitter's test strip, a membrane strip pre-coated with a specific set of antigens in parallel lines. If antibodies to any of those antigens are present in the patient's serum, they will bind to the specific antigen. The bound patient antibodies are then detected using labelled anti-human antibodies. Manufacturers call this method by different names, including immunoblot, line blot, and line immunoassay. LOINC uses the immunoblot (IB) method to mean that some electrophoretic/chromatographic separation occurs such that position (size) of the band is part of the assessment (as in Western blot). Because this assay does not involve a separation step but rather uses strips with pre-fixed antigens, the LOINC Method for this term is Line blot.
Source: Regenstrief LOINC

Part Descriptions

LP15673-4   Intrinsic factor
Intrinsic factor is a glycoprotein produced by the parietal cells of the stomach. It is necessary for the absorption of vitamin B12 later on in the small intestine. Upon entry into the stomach, vitamin B12 becomes bound to one of two B12 binding proteins present in gastric juice. In the less acidic environment of the small intestine, these proteins dissociate from the vitamin, enabling it to bind to intrinsic factor and enter the portal circulation through a receptor in the ileal mucosa specific for the B12 -intrinsic factor complex. In pernicious anemia, an autoimmune disease, autoantibodies directed against intrinsic factor or parietal cells themselves lead to an intrinsic factor deficiency, malabsorption of vitamin B12, and subsequent megaloblastic anemia. Atrophic gastritis can also cause intrinsic factor deficiency and anemia through damage to the parietal cells of the stomach wall. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, intrinsic factor (Wikipedia)

LP15673-4   Intrinsic factor
A glycoprotein secreted by the cells of the gastric glands that is required for the absorption of VITAMIN B 12. Deficiency of intrinsic factor results in ANEMIA, PERNICIOUS. Source: National Library of Medicine, MeSH 2006

Fully-Specified Name

Component
Intrinsic factor Ab
Property
PrThr
Time
Pt
System
Ser
Scale
Ord
Method
Line blot

Additional Names

Short Name
IF Ab Ser Ql Line blot
Display Name
Intrinsic factor Ab Line blot Ql (S)
Consumer Name Alpha
Intrinsic factor antibody, Blood

Example Answer List LL744-4

Source: Regenstrief Institute

Answer Code Score Answer ID
Detected LA11882-0
Not detected LA11883-8

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.64
Last Updated
Version 2.64
Order vs. Observation
Both

Member of these Groups

LG8731-4 Intrinsic factor Ab|PrThr|Pt|ANYBldSerPl

Language Variants Get Info

zh-CNChinese (China)
内因子 抗体:存在情况或阈值:时间点:血清:序数型:线点印迹法
nl-NLDutch (Netherlands)
intrinsieke factor As:aanwezigheid:moment:serum:ordinaal:lijnblot
fr-CAFrench (Canada)
Facteur intrinsèque , Ac:Présence-Seuil:Temps ponctuel:Sérum:Ordinal:Immunoessai sur bandelette
fr-FRFrench (France)
Facteur intrinsèque anticorps:Présence/Seuil:Ponctuel:Sérum:Qualitatif:Blot en ligne
it-ITItalian (Italy)
Fattore intrinseco Ab:PrThr:Pt:Siero:Ord:Line blot
pl-PLPolish (Poland)
czynnik wewnętrzny przeciwciało:obecność lub wartość progowa:Punkt w czasie:Surowica:Porządkowy:Line blot
es-MXSpanish (Mexico)
Factor intrínseco Ab:Presencia o umbral:Punto temporal:Suero:Ordinal:Mancha de línea
es-ESSpanish (Spain)
Factor intrínseco Anticuerpos:PrThr:Punto temporal:Suero:Ord:Line blot

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=89508-6