LOINC
Version 2.72

89517-7Ganglioside GM2 IgG+IgM Ab [Presence] in Serum by Line blotActive

Term Description

This term was created for, but is not limited in use to, the submitter's test strip, a membrane strip pre-coated with a specific set of antigens in parallel lines. If antibodies to any of those antigens are present in the patient's serum, they will bind to the specific antigen. The bound patient antibodies are then detected using labelled anti-human antibodies. Manufacturers call this method by different names, including immunoblot, line blot, and line immunoassay. LOINC uses the immunoblot (IB) method to mean that some electrophoretic/chromatographic separation occurs such that position (size) of the band is part of the assessment (as in Western blot). Because this assay does not involve a separation step but rather uses strips with pre-fixed antigens, the LOINC Method for this term is Line blot.
Source: Regenstrief LOINC

Part Descriptions

LP62853-4   Ganglioside GM2
Gangliosides are present in the cell membrane and are found predominantly in the nervous system. Ganglioside antibodies against different gangliosides have been associated with different conditions. The GM2 ganglioside, also called Tay-Sachs ganglioside, is a minor component of adult nervous tissue, and pathological storage of GM2 in neurons leads to motor neuron disease. Anti-GM2 IgM antibodies have been found in patients with Guillain-Barré syndrome that is associated with CMV infection. Anti-GM2 antibodies have also been associated with an acute inflammatory neuropathy as a potentially paraneoplastic phenomenon. [PMID:23341581] Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Regenstrief LOINC, PMID: 23341581

LP222219-0   Ganglioside
A ganglioside molecule consists of a glycosphingolipid (ceramide and oligosaccharide) with one or more sialic acid residues linked to the sugar chain. Molecules with one sialic acid residue are called monosialogangliosides (GM), those with two are called disialogangliosides (GD), and those with three are trisialogangliosides (GT). Gangliosides without any sialic acid residues are called asialogangliosides, while those that do not have a ceramide N-acyl group are called lysogangliosides. The number that typically is included at the end of the name indicates the order in which the molecule was discovered. For example, GM2 is a ganglioside with one sialic acid residue that was the second GM to be identified. Source: Regenstrief LOINC

Fully-Specified Name

Component
Ganglioside GM2 Ab.IgG+IgM
Property
PrThr
Time
Pt
System
Ser
Scale
Ord
Method
Line blot

Additional Names

Short Name
GM2 Gangl IgG+IgM Ser Ql Line blot
Display Name
Ganglioside GM2 IgG+IgM Line blot Ql (S)
Consumer Name Alpha
Ganglioside GM2 IgG+IgM, Blood

Example Answer List LL744-4

Source: Regenstrief Institute

Answer Code Score Answer ID
Detected LA11882-0
Not detected LA11883-8

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.64
Last Updated
Version 2.64
Order vs. Observation
Both

Member of these Panels

LOINC Long Common Name
82455-7 Ganglioside Ab panel - Serum

Member of these Groups

LG26352-1 Ganglioside GM2 Ab.IgG+IgM|PrThr|Pt|ANYBldSerPl

Language Variants Get Info

zh-CNChinese (China)
神经节苷脂 GM2 抗体.IgG+IgM:存在情况或阈值:时间点:血清:序数型:线点印迹法
nl-NLDutch (Netherlands)
ganglioside GM2 As.IgG + IgM:aanwezigheid:moment:serum:ordinaal:lijnblot
fr-CAFrench (Canada)
Ganglioside GM2 , IgG+IgM:Présence-Seuil:Temps ponctuel:Sérum:Ordinal:Immunoessai sur bandelette
fr-FRFrench (France)
Ganglioside GM2 anticorps IgG+IgM:Présence/Seuil:Ponctuel:Sérum:Qualitatif:Blot en ligne
it-ITItalian (Italy)
Ganglioside GM2 Ab.IgG+IgM:PrThr:Pt:Siero:Ord:Line blot
es-MXSpanish (Mexico)
Gangliósido GM2 Ab.IgG + IgM:Presencia o umbral:Punto temporal:Suero:Ordinal:Mancha de línea
es-ESSpanish (Spain)
Gangliósido GM2 IgG+IgM:PrThr:Punto temporal:Suero:Ord:Line blot

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=89517-7