LOINC
Version 2.72

89526-8Sjogrens syndrome-B extractable nuclear Ab [Presence] in Cerebral spinal fluid by Line blotActive

Term Description

This term was created for, but is not limited in use to, the submitter's test strip, a membrane strip pre-coated with a specific set of antigens in parallel lines. If antibodies to any of those antigens are present in the patient's serum, they will bind to the specific antigen. The bound patient antibodies are then detected using labelled anti-human antibodies. Manufacturers call this method by different names, including immunoblot, line blot, and line immunoassay. LOINC uses the immunoblot (IB) method to mean that some electrophoretic/chromatographic separation occurs such that position (size) of the band is part of the assessment (as in Western blot). Because this assay does not involve a separation step but rather uses strips with pre-fixed antigens, the LOINC Method for this term is Line blot.
Source: Regenstrief LOINC

Part Description

LP16761-6   Sjogrens syndrome-B extractable nuclear
Sjogren syndrome type A antigen (also known as SS-A, Ro, and E3 ubiquitin-protein ligase TRIM21) and Sjogren syndrome type B antigen (also known as SS-B and Lupus La protein) are nuclear antigens to which autoantibodies develop in autoimmune disorders such as Sjogren's syndrome (SS) and systemic lupus erythematosus (SLE). Between 40 and 70% of patients with SS have anti-SSA and/or anti-SSB autoantibodies, and 30-40% and 10-15% of patients with SLE are anti-SSA and anti-SSB positive, respectively. Longitudinal studies have shown that anti-SSA and -SSB antibodies may be present up to 20 years before the clinical onset of disease. SS patients who are anti-SSA and anti-SSB positive may have longer disease duration, parotid gland enlargement, decreased salivary flow, more severe minor salivary gland infiltration and a higher prevalence of extraglandular manifestations. [PMID:27184054] Source: Regenstrief LOINC, PMID: 27184054

Fully-Specified Name

Component
Sjogrens syndrome-B extractable nuclear Ab
Property
PrThr
Time
Pt
System
CSF
Scale
Ord
Method
Line blot

Additional Names

Short Name
ENA SS-B Ab CSF Ql Line blot
Display Name
Sjogrens syndrome-B extractable nuclear Ab Line blot Ql (CSF)
Consumer Name Alpha
Sjogrens syndrome-B extractable nuclear antibody, Spinal fluid

Example Answer List LL744-4

Source: Regenstrief Institute

Answer Code Score Answer ID
Detected LA11882-0
Not detected LA11883-8

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.64
Last Updated
Version 2.64
Order vs. Observation
Both

Member of these Groups

LG29267-8 Sjogrens syndrome-B extractable nuclear Ab|PrThr|Pt|CSF

Language Variants Get Info

zh-CNChinese (China)
Sjogrens 综合征-b 可提取性核 抗体:存在情况或阈值:时间点:脑脊液:序数型:线点印迹法
nl-NLDutch (Netherlands)
SS-B extraheerbare nucleaire As:aanwezigheid:moment:liquor cerebrospinalis:ordinaal:lijnblot
fr-CAFrench (Canada)
Syndrome de Sjögren-b nucléaire soluble , Ac:Présence-Seuil:Temps ponctuel:LCR:Ordinal:Immunoessai sur bandelette
fr-FRFrench (France)
SSB/La anticorps:Présence/Seuil:Ponctuel:Liquide céphalorachidien:Qualitatif:Blot en ligne
it-ITItalian (Italy)
Sjogren, sindrome-nucleare estraibile B Ab:PrThr:Pt:LCS:Ord:Line blot
es-MXSpanish (Mexico)
Ab nuclear extraíble con síndrome de Sjogrens-B:Presencia o umbral:Punto temporal:Fluído espinal cerebral:Ordinal:Mancha de línea
es-ESSpanish (Spain)
Antígeno nuclear extraíble Síndrome de Sjogren-B (SS-B) Anticuerpos:PrThr:Punto temporal:Líquido Cefalorraquideo:Ord:Line blot

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=89526-8