89533-4SCL-70 extractable nuclear Ab [Presence] in Cerebral spinal fluid by Line blotActive
Term Description
This term was created for, but is not limited in use to, the submitter's test strip, a membrane strip pre-coated with a specific set of antigens in parallel lines. If antibodies to any of those antigens are present in the patient's serum, they will bind to the specific antigen. The bound patient antibodies are then detected using labelled anti-human antibodies. Manufacturers call this method by different names, including immunoblot, line blot, and line immunoassay. LOINC uses the immunoblot (IB) method to mean that some electrophoretic/chromatographic separation occurs such that position (size) of the band is part of the assessment (as in Western blot). Because this assay does not involve a separation step but rather uses strips with pre-fixed antigens, the LOINC Method for this term is Line blot.
Source: Regenstrief LOINC
Part Description
LP16758-2 SCL-70 extractable nuclear
Topoisomerase I (also known as Scl-70) is a nuclear enzyme that plays a role in releasing tension that is introduced in double-stranded DNA during DNA replication by transiently cleaving and rejoining one strand of the DNA duplex. Anti-Scl-70 autoantibodies are a marker of systemic sclerosis as well as other autoimmune diseases, including systemic lupus erythematosus (SLE). In patients with systemic sclerosis, anti-SCL-70 may be associated with more severe disease, and in patients with SLE, anti-SCL-70 suggests an increased risk of pulmonary hypertension and renal involvement. In general, anti-SCL-70 antibody status may help with diagnosis, treatment planning and prognosis in patients with connective tissue disease. [PMID:11229469]
Source: Regenstrief LOINC, PMID: 11229469
Fully-Specified Name
- Component
- SCL-70 extractable nuclear Ab
- Property
- PrThr
- Time
- Pt
- System
- CSF
- Scale
- Ord
- Method
- Line blot
Additional Names
- Short Name
- ENA Scl70 Ab CSF Ql Line blot
- Display Name
- SCL-70 extractable nuclear Ab Line blot Ql (CSF)
- Consumer Name Alpha
- SCL-70 extractable nuclear antibody, Spinal fluid
Example Answer List LL744-4
Source: Regenstrief Institute
Answer | Code | Score | Answer ID |
---|---|---|---|
Detected | LA11882-0 | ||
Not detected | LA11883-8 |
Basic Attributes
- Class
- SERO
- Type
- Laboratory
- First Released
- Version 2.64
- Last Updated
- Version 2.64
- Order vs. Observation
- Both
Member of these Groups
LG26773-8 | SCL-70 extractable nuclear Ab| |
Language Variants Get Info
- zh-CNChinese (China)
- SCL-70 可提取性核 抗体:
存在情况或阈值: 时间点: 脑脊液: 序数型: 线点印迹法 - nl-NLDutch (Netherlands)
- SCL-70 extraheerbare nucleaire As:
aanwezigheid: moment: liquor cerebrospinalis: ordinaal: lijnblot - fr-CAFrench (Canada)
- SCL-70 nucléaire soluble , Ac:
Présence-Seuil: Temps ponctuel: LCR: Ordinal: Immunoessai sur bandelette - fr-FRFrench (France)
- SCL-70 anticorps:
Présence/Seuil: Ponctuel: Liquide céphalorachidien: Qualitatif: Blot en ligne - it-ITItalian (Italy)
- Nucleare estraibile SCL-70 Ab:
PrThr: Pt: LCS: Ord: Line blot - es-MXSpanish (Mexico)
- Ab nuclear extraíble SCL-70:
Presencia o umbral: Punto temporal: Fluído espinal cerebral: Ordinal: Mancha de línea - es-ESSpanish (Spain)
- Antígeno nuclear extraíble SCL-70 Anticuerpos:
PrThr: Punto temporal: Líquido Cefalorraquideo: Ord: Line blot
LOINC FHIR® API Example - CodeSystem Request Get Info
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=89533-4
LOINC Copyright
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