Version 2.72

89533-4SCL-70 extractable nuclear Ab [Presence] in Cerebral spinal fluid by Line blotActive

Term Description

This term was created for, but is not limited in use to, the submitter's test strip, a membrane strip pre-coated with a specific set of antigens in parallel lines. If antibodies to any of those antigens are present in the patient's serum, they will bind to the specific antigen. The bound patient antibodies are then detected using labelled anti-human antibodies. Manufacturers call this method by different names, including immunoblot, line blot, and line immunoassay. LOINC uses the immunoblot (IB) method to mean that some electrophoretic/chromatographic separation occurs such that position (size) of the band is part of the assessment (as in Western blot). Because this assay does not involve a separation step but rather uses strips with pre-fixed antigens, the LOINC Method for this term is Line blot.
Source: Regenstrief LOINC

Part Description

LP16758-2   SCL-70 extractable nuclear
Topoisomerase I (also known as Scl-70) is a nuclear enzyme that plays a role in releasing tension that is introduced in double-stranded DNA during DNA replication by transiently cleaving and rejoining one strand of the DNA duplex. Anti-Scl-70 autoantibodies are a marker of systemic sclerosis as well as other autoimmune diseases, including systemic lupus erythematosus (SLE). In patients with systemic sclerosis, anti-SCL-70 may be associated with more severe disease, and in patients with SLE, anti-SCL-70 suggests an increased risk of pulmonary hypertension and renal involvement. In general, anti-SCL-70 antibody status may help with diagnosis, treatment planning and prognosis in patients with connective tissue disease. [PMID:11229469] Source: Regenstrief LOINC, PMID: 11229469

Fully-Specified Name

SCL-70 extractable nuclear Ab
Line blot

Additional Names

Short Name
ENA Scl70 Ab CSF Ql Line blot
Display Name
SCL-70 extractable nuclear Ab Line blot Ql (CSF)
Consumer Name Alpha
SCL-70 extractable nuclear antibody, Spinal fluid

Example Answer List LL744-4

Source: Regenstrief Institute

Answer Code Score Answer ID
Detected LA11882-0
Not detected LA11883-8

Basic Attributes

First Released
Version 2.64
Last Updated
Version 2.64
Order vs. Observation

Member of these Groups

LG26773-8 SCL-70 extractable nuclear Ab|PrThr|Pt|CSF

Language Variants Get Info

zh-CNChinese (China)
SCL-70 可提取性核 抗体:存在情况或阈值:时间点:脑脊液:序数型:线点印迹法
nl-NLDutch (Netherlands)
SCL-70 extraheerbare nucleaire As:aanwezigheid:moment:liquor cerebrospinalis:ordinaal:lijnblot
fr-CAFrench (Canada)
SCL-70 nucléaire soluble , Ac:Présence-Seuil:Temps ponctuel:LCR:Ordinal:Immunoessai sur bandelette
fr-FRFrench (France)
SCL-70 anticorps:Présence/Seuil:Ponctuel:Liquide céphalorachidien:Qualitatif:Blot en ligne
it-ITItalian (Italy)
Nucleare estraibile SCL-70 Ab:PrThr:Pt:LCS:Ord:Line blot
es-MXSpanish (Mexico)
Ab nuclear extraíble SCL-70:Presencia o umbral:Punto temporal:Fluído espinal cerebral:Ordinal:Mancha de línea
es-ESSpanish (Spain)
Antígeno nuclear extraíble SCL-70 Anticuerpos:PrThr:Punto temporal:Líquido Cefalorraquideo:Ord:Line blot

LOINC FHIR® API Example - CodeSystem Request Get Info