Version 2.72

89542-5Centromere protein B Ab [Presence] in Cerebral spinal fluid by Line blotActive

Term Description

This term was created for, but is not limited in use to, the submitter's test strip, a membrane strip pre-coated with a specific set of antigens in parallel lines. If antibodies to any of those antigens are present in the patient's serum, they will bind to the specific antigen. The bound patient antibodies are then detected using labelled anti-human antibodies. Manufacturers call this method by different names, including immunoblot, line blot, and line immunoassay. LOINC uses the immunoblot (IB) method to mean that some electrophoretic/chromatographic separation occurs such that position (size) of the band is part of the assessment (as in Western blot). Because this assay does not involve a separation step but rather uses strips with pre-fixed antigens, the LOINC Method for this term is Line blot.
Source: Regenstrief LOINC

Part Description

LP71684-2   Centromere protein B Ab
Major centromere autoantigen B, also known as centromere protein B or CENP-B, is encoded by the CENPB gene located on chromosome 20p13. CENP-B interacts with chromosomal centromeric heterochromatin and binds to a specific subset of alphoid satellite DNA, called the CENP-B box. [UniProt:P07199] CENP-B plays a direct role in stablizing CENP-C, which is a kinetochore assembly nucleator, and recruiting CENP-A, which marks and maintains centromere position. Chromosomes that have centromeres without bound CENP-B, including the human Y chromosome, are more likely to missegregate at much higher rates than chromosomes with CENP-B containing centromeres. [PMID:25942623] Autoantibodies to both CENP-A and CENP-B are markers for scleroderma and other rheumatic diseases. [PMID:17210244] Source: Regenstrief LOINC, UniProt: P07199

Fully-Specified Name

Centromere protein B Ab
Line blot

Additional Names

Short Name
Centromere B Ab CSF Ql Line blot
Display Name
Centromere protein B Ab Line blot Ql (CSF)
Consumer Name Alpha
Centromere Protein B antibody, Spinal fluid

Example Answer List LL744-4

Source: Regenstrief Institute

Answer Code Score Answer ID
Detected LA11882-0
Not detected LA11883-8

Basic Attributes

First Released
Version 2.64
Last Updated
Version 2.64
Order vs. Observation

Member of these Groups

LG29561-4 Centromere protein B Ab|PrThr|Pt|CSF

Language Variants Get Info

zh-CNChinese (China)
着丝点蛋白 B 抗体:存在情况或阈值:时间点:脑脊液:序数型:线点印迹法
nl-NLDutch (Netherlands)
centromeereiwit B As:aanwezigheid:moment:liquor cerebrospinalis:ordinaal:lijnblot
fr-CAFrench (Canada)
Centromère protéine B , Ac:Présence-Seuil:Temps ponctuel:LCR:Ordinal:Immunoessai sur bandelette
fr-FRFrench (France)
Centromère protéine B anticorps:Présence/Seuil:Ponctuel:Liquide céphalorachidien:Qualitatif:Blot en ligne
it-ITItalian (Italy)
Centromero, proteina B Ab:PrThr:Pt:LCS:Ord:Line blot
es-MXSpanish (Mexico)
Centrómero de proteína B Ab:Presencia o umbral:Punto temporal:Fluído espinal cerebral:Ordinal:Mancha de línea
es-ESSpanish (Spain)
Proteína B del centrómero Anticuerpos:PrThr:Punto temporal:Líquido Cefalorraquideo:Ord:Line blot

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