Version 2.73

90815-2Amphiphysin Ab [Presence] in Cerebral spinal fluid by ImmunofluorescenceActive

Part Descriptions

LP30843-4   Amphiphysin
Amphiphysin is a protein associated with the cytoplasmic surface of synaptic vesicles and is encoded by the AMPH gene. Patients with stiff man syndrome and breast cancer can be positive with autoantibodies against the amphiphysin protein. Source: Regenstrief LOINC

LP37039-2   Amphiphysin Ab
Paraneoplastic syndromes (PNS) are diseases associated with remote effects of tumors, of which small-cell lung cancer (SCLC), ovarian cancer, breast cancer, thymoma, Hodgkin lymphoma, and testicular cancer are the most common. Stiff-person syndrome (SPS) is a rare neurological disorder characterized by stiffness of skeletal muscles with superimposed spasms, which can have an idiopathic or paraneoplastic component. First described in women with breast cancer and SPS, amphiphysin antibodies have been reported in patients with diverse paraneoplastic neurological disorders, and cancers. Amphiphysin antibodies are considered diagnosic for paraneoplastic neurologic syndromes and can direct the search for an occult tumor, recurrence of tumor, or second tumor. Source: ARUP Laboratories

LP37039-2   Amphiphysin Ab
Amphiphysin is a brain-enriched protein normally found only within the membrane of synaptic vesicles in neural tissue. Antibodies against amphiphysin (128kDa) are directed against the protein amphiphysin, and their presence plays an important diagnostic role in paraneoplastic syndromes (e.g. Lambert Eaton myasthenia syndrome, encephalomyelitis with rigidity, cerebellar syndrome, sensory neuronopathy, opsoclonus myoclonus ataxia, and Stiff-man syndrome). Paraneoplastic syndromes are autoantibody-mediated neurologic disorders most commonly associated with cancers of the lung, breast, ovaries or lymphatic system. Source: Regenstrief LOINC

Fully-Specified Name

Amphiphysin Ab

Additional Names

Short Name
Amphiphysin Ab CSF Ql IF
Display Name
Amphiphysin Ab IF Ql (CSF)
Consumer Name Alpha
Amphiphysin antibody, Spinal fluid

Example Answer List LL2038-9

Source: Quest Diagnostics Inc.

Answer Code Score Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6
Indeterminate Copyright http://snomed.info/sct ID:82334004 Indeterminate (qualifier value) LA11884-6

Basic Attributes

First Released
Version 2.65
Last Updated
Version 2.65
Order vs. Observation

Member of these Panels

LOINC Long Common Name
94818-2 Paraneoplastic Ab panel - Cerebral spinal fluid by Immunofluorescence

Member of these Groups

LG24036-2 Amphiphysin Ab|PrThr|Pt|CSF

Language Variants Get Info

zh-CNChinese (China)
双载蛋白 抗体:存在情况或阈值:时间点:脑脊液:序数型:免疫荧光法
nl-NLDutch (Netherlands)
amfifysine As:aanwezigheid:moment:liquor cerebrospinalis:ordinaal:immunofluorescentie
et-EEEstonian (Estonia)
Amfifüsiin antikehad:PrThr:Pt:CSF:Ord:IF
fr-BEFrench (Belgium)
Amphiphysine Ac:PrThr:Temps ponctuel:LCR:Ordinal:Immunofluorescence
fr-CAFrench (Canada)
Amphiphysine , Ac:Présence-Seuil:Temps ponctuel:LCR:Ordinal:Immunofluorescence
fr-FRFrench (France)
Amphiphysine anticorps:Présence/Seuil:Ponctuel:Liquide céphalorachidien:Qualitatif:Immunofluorescence
it-ITItalian (Italy)
Amfifisina Ab:PrThr:Pt:LCS:Ord:IF
ru-RURussian (Russian Federation)
Амфифизин Ат:PrThr:ТчкВрм:ЦСЖ:Пор:ИФ
es-MXSpanish (Mexico)
Amphiphysin Ab:Presencia o umbral:Punto temporal:Fluído espinal cerebral:Ordinal:Inmunofluorescencia (IF)
es-ESSpanish (Spain)
Anfifisina Anticuerpos:PrThr:Punto temporal:Líquido Cefalorraquideo:Ord:Inmunofluorescencia (IF)
tr-TRTurkish (Turkey)
Amfifizin Ab:MevcEşik:Zmlı:BOS:Srl:IF

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