LOINC
Version 2.72

91791-4Varicella zoster virus DNA [Presence] in Upper respiratory specimen by NAA with probe detectionActive

Part Description

LP14853-3   Varicella zoster virus
Varicella zoster virus (VZV) is a double-stranded alphaherpesvirus that causes seasonal outbreaks of chickenpox and shingles in non-immunized populations. VZV is highly infectious and is transmitted by contact with the ruptured fluid filled blisters and respiratory secretions of infected individuals. Immunity post infection is usually lifelong though the latent virus inhabits the sensory nerve ganglia where it can reactivate causing shingles when immunity declines with aging.[http://jvi.asm.org/content/88/24/13936.full] In the over fifty strains of VZV that have been sequenced it has been found that a single nucleotide polymorphism occurs about every 100 bases. The patterns of polymorphisms in VZV correlate with different geographical regions of infection and is the basis for the classification of viral clades.[https://grose.lab.uiowa.edu/vzv-genomes-and-evolution] Breuer proposed the nomenclature for the VZV clades as 1-5 with the suspected clades VI and VII to be confirmed later. The geographical regions associated with the seven clades are as follows:
Clades 1 and 3-represent the dominant clades of the circulating VZV in Europe and the Americas
Clades 4 and 5-found in Africa
Clade VI found in France, Italy
Clade VII exclusively isolated in the US
Clade 2-Asia from Korea, Japan, China not found in India, Nepal and Bangladesh where clades 4 and 5 were dominant
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054591/ Source: Regenstrief LOINC

Fully-Specified Name

Component
Varicella zoster virus DNA
Property
PrThr
Time
Pt
System
Respiratory.upper
Scale
Ord
Method
Probe.amp.tar

Additional Names

Short Name
VZV DNA Upper resp Ql NAA+probe
Display Name
VZV DNA NAA+probe Ql (Upper resp)
Consumer Name Alpha
Varicella zoster virus (VZV; Chickenpox), Upper respiratory

Example Answer List LL744-4

Source: Regenstrief Institute

Answer Code Score Answer ID
Detected LA11882-0
Not detected LA11883-8

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.66
Last Updated
Version 2.68
Order vs. Observation
Both

Member of these Groups

LG32750-8 Varicella zoster virus
LG50851-1 Varicella zoster virus DNA|PrThr|Sys:ANYResp

Language Variants Get Info

zh-CNChinese (China)
水痘带状疱疹病毒 DNA:存在情况或阈值:时间点:呼吸道.上:序数型:探针法.基因扩增.靶向
nl-NLDutch (Netherlands)
varicella-zostervirus DNA:aanwezigheid:moment:bovenste luchtwegen:ordinaal:moleculaire techniek (PCR)
fr-FRFrench (France)
Varicelle zona virus ADN:Présence/Seuil:Ponctuel:Voies respiratoires supérieures:Qualitatif:PCR amplification de cible
it-ITItalian (Italy)
Varicella zoster, virus DNA:PrThr:Pt:Sistema respiratorio.superiore:Ord:Sonda.amp.tar
es-MXSpanish (Mexico)
ADN del virus de la varicela zóster:Presencia o umbral:Punto temporal:Muestra respiratoria superior:Ordinal:Amplificación de ácidos nucleicos con detección de sonda
es-ESSpanish (Spain)
Virus Varicella zoster ADN:PrThr:Punto temporal:Muestra respiratoria de vías altas:Ord:Sonda con amplificación dirigida

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=91791-4