LOINC
Version 2.66

92636-0APOL1 inferred genotype [Identifier] in Plasma from DonorActive

Component
APOL1 inferred genotype
Property
Prid
Time
Pt
System
Plas^Donor
Scale
Nom
Method

Additional Names

Short Name
APOL1 inferred Gentyp Plas Donr
Display Name Beta
APOL1 inferred genotype Nom (P donor)
Consumer Name Alpha
APOL1 Inferred genotype, Donor Blood

Part Description

LP310321-7   APOL1 inferred genotype
The APOL1 gene encodes apolipoprotein L1, which is a component of high density lipoprotein (HDL). Two variants of APOL1, called G1 and G2, are associated with significantly increased risk for chronic kidney diseases such as HIV-associated nephropathy, focal segmental glomerulosclerosis, and end-stage kidney disease due to hypertension. Increased risk occurs in people with sub-Saharan African ancestry that have at least one copy of G1 or G2, and the highest risk is in those with two copies of any combination of G1 and G2. African-American patients have been found to have a four-fold increased lifetime risk for end-stage kidney disease. From an evolutionary standpoint, the G1 and G2 protein isoforms, but not the wild type form, protect against Trypanosoma brucei rhodesiense infection (known as African sleeping sickness), which may have led to an increased frequency of these variants in places where Trypanosoma is more prevalent. [PMID: 30417125] Kidneys from donors that have homozygous or heterozygous expression of high-risk APOL1 variants (i.e., G1/G1, G1/G2, G2/G2) have a higher risk of failure compared to those from donors who have at least one copy of wild type APOL1 (G0). Donor information about APOL1 may help inform the kidney donation and selection process. [PMID: 25826538] Source: Regenstrief LOINC

Basic Attributes

Class
MOLPATH
Type
Laboratory
First Released
Version 2.66
Last Updated
Version 2.66
Order vs. Observation
Both

Preferred Answer List LL5284-6

Source: Regenstrief LOINC

Answer Code Score Answer ID
APOL1 Homozygous wild type LA29894-5
APOL1 Heterozygous wild type/G1 LA29895-2
APOL1 Heterozygous wild type/G2 LA29896-0
APOL1 Homozygous G1/G1 LA29898-6
APOL1 Homozygous G2/G2 LA29899-4
APOL1 Heterozygous G1/G2 LA29897-8

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