LOINC
Version 2.73

92896-0Aldosterone [Mass/volume] in Serum or Plasma by Radioimmunoassay (RIA)Active

Term Description

Aldosterone concentration measured by radioimmunoassay (RIA) and chemiluminescent immunoassay are well-correlated; however, they have different reference ranges. [PMID:29115296]
This term is for aldosterone measurement by RIA. For aldosterone concentration measured by immunoassay methods such as chemiluminescence, see [LOINC:92897-8].
Source: Regenstrief LOINC

Part Descriptions

LP14377-3   Aldosterone
Aldosterone is a steroid hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland to regulate sodium and potassium balance in the blood. It is synthesized from cholesterol by aldosterone synthase, which is absent in other sections of the adrenal gland. It is the sole endogenous member of the class of mineralocorticoids. Acting on mineralocorticoid receptors (MR) on principal cells in the collecting ducts of the kidneys, it increases the permeability of their apical (luminal) membrane to potassium and sodium and activates their basolateral Na+K+ pumps, stimulating ATP hydrolysis, reabsorbing sodium (Na+) ions and water into the blood, and excreting potassium (K+) ions into the urine. Aldosterone also stimulates H+ secretion by intercalated cells in the collecting duct, regulating plasma bicarbonate (HCO3-) levels and its acidbase balance. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Aldosterone (Wikipedia)

LP14377-3   Aldosterone
Used to detect hyper and hypo aldosteronisnm. Hypoaldosteronism can occur in any condition that causes destruction or dysfunction of the adrenal gland.1,2,4 Hypoaldosterism can be due to primary adrenal insufficiency , congenital adrenal hypoplasia, acquired secondary aldosterone deficiency (hyporeninemic hypoaldosteronism), and acquired Hyporeninemic hypoaldosteronism is the most common form of isolated hypoaldosteronism and is results from impaired renin release from the kidney. Congenital hypoaldosteronism caused by inherited enzymatic defects in aldosterone biosynthesis are rare. Corticosterone methyloxidase I (CMO I) deficiency is associated with elevated serum levels of corticosterone and low levels of 18-hydroxy-corticosterone and aldosterone. Corticosterone methyloxidase II (CMO II) deficiency produces high levels of 18-hydroxy-corticosterone, the immediate precursor of aldosterone.
Acquired primary hypoaldosteronism can be caused by the administration of heparin. Also, persistently hypotensive, critically ill patients with sepsis, pneumonia, peritonitis, cholangitis, and liver failure can have inappropriately low plasma aldosterone concentrations in relation to elevated plasma renin activity. Primary hyperaldosteronism, also referred to as Conn syndrome, is due to overproduction of aldosterone by one or both of the adrenal glands. Some recent studies suggest that 10% to 15% of Hyper thyroidism cases are due to (or associated with ) primary hyperaldosteronism. Secondary hyperaldosteronism is relatively common and can occur as the result of any condition that decreases blood flow to the kidneys (ie, renal artery stenosis), decreases blood pressure, or lowers plasma sodium levels. Secondary hyperaldosteronism may also be seen with cirrhosis, congestive heart failure. and toxemia of pregnancy. Several studies have suggested that high-normal aldosterone levels predict development of high blood pressure in normotensive subjects and that increased aldosterone action contributes to hypertension, cardiovascular fibrosis, and cardiac hypertrophy. Source: Regenstrief Institute

Fully-Specified Name

Component
Aldosterone
Property
MCnc
Time
Pt
System
Ser/Plas
Scale
Qn
Method
RIA

Additional Names

Short Name
Aldost SerPl RIA-mCnc
Display Name
Aldosterone RIA [Mass/Vol]
Consumer Name Alpha
Aldosterone, Blood

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.66
Last Updated
Version 2.66
Order vs. Observation
Both

Member of these Groups

LG5179-9 Aldosterone|MCnc|Pt|ANYBldSerPl

Language Variants Get Info

zh-CNChinese (China)
醛固酮:质量浓度:时间点:血清/血浆:定量型:放射免疫分析法
nl-NLDutch (Netherlands)
aldosteron:massa/volume:moment:serum of plasma:kwantitatief:RIA
et-EEEstonian (Estonia)
Aldosteroon:MCnc:Pt:S/P:Qn:RIA
fr-BEFrench (Belgium)
Aldostérone:Concentration de masse:Temps ponctuel:Sérum/Plasma:Quantitatif:RIA
fr-CAFrench (Canada)
Aldostérone:Concentration de masse:Temps ponctuel:Sérum/Plasma:Quantitatif:RIA
fr-FRFrench (France)
Aldostérone:Masse/Volume:Ponctuel:Sérum/Plasma:Numérique:Radioimmunoanalyse
de-DEGerman (Germany)
Aldosteron:Massenkonzentration:Zeitpunkt:Serum oder Plasma:Quantitativ:Radioimmunoassay
it-ITItalian (Italy)
Aldosterone:MCnc:Pt:Siero/Plasma:Qn:RIA
ru-RURussian (Russian Federation)
Альдостерон:МассКонц:ТчкВрм:Сыв/Плаз:Колич:РИА
es-MXSpanish (Mexico)
Aldosterona:Concentración de masa:Punto temporal:Suero o Plasma:Cuantitativo:Radioinmunoensayo (RIA)
es-ESSpanish (Spain)
Aldosterona:Concentración de masa:Punto temporal:Suero o Plasma:Qn:Radioinmunoensayo (RIA)
tr-TRTurkish (Turkey)
Aldosteron:KütlKons:Zmlı:Ser/Plaz:Kant:RIA

Example Units

Unit Source
ng/dL Example UCUM Units

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=92896-0