93371-3
von Willebrand factor (vWf) cleaving protease activity [Enzymatic activity/volume] in Platelet poor plasma by Chromogenic method
Active
Part Description
LP410874-4 von Willebrand factor cleaving protease activity
von Willebrand factor (vWF) cleaving protease, or ADAMTS13, is a metalloprotease that cleaves vWF and thereby limits platelet aggregation and formation of microthrombi. vWF cleaving protease inhibitors can decrease the protease activity and/or more rapidly remove the enzyme from the circulation. Such inhibitors are one cause of thrombotic thrombocytopenic purpura (TTP), a disorder characterized by thrombocytopenia, anemia, fever, and neurologic and renal abnormalities. Idiopathic TTP is often due to anti-ADAMTS13 autoantibodies, while inherited TTP is an autosomal recessive disorder due to mutations in the ADAMTS13 gene that lead to impaired protease function. Work-up of patients with TTP can include vWF cleaving protease activity and, if that activity is low, inhibitor screen followed by quantification. PMID: 18756543
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- von Willebrand factor cleaving protease activity
- Property
- CCnc
- Time
- Pt
- System
- PPP
- Scale
- Qn
- Method
- Chromo
Additional Names
- Short Name
- vWF Cp Act PPP Chro-cCnc
- Display Name
- vWf cleaving protease activity Chromogenic method (PPP) [Catalytic activity/Vol]
- Consumer Name Alpha Get Info
- vWf cleaving protease activity, Blood
Basic Attributes
- Class
- COAG
- Type
- Laboratory
- First Released
- Version 2.67
- Last Updated
- Version 2.68
- Order vs. Observation
- Both
Language Variants Get Info
Tag | Language | Translation |
---|---|---|
es-ES | Spanish (Spain) | Actividad de la proteasa de escisión del factor de von Willebrand: Synonyms: Cuantitativo |
es-MX | Spanish (Mexico) | Factor de von Willebrand que escinde la actividad de la proteasa: |
fr-FR | French (France) | ADAMTS 13 activité: |
it-IT | Italian (Italy) | von Willebrand, fattore attività proteasi di taglio: Synonyms: Attività della proteasi di taglio del fattore di von Willebrand Concentrazione Catalitica Cromogenico (Enzima) Fattore di von Willebrand (vWf) Plasma povero di piastrine Proteasi di taglio del fattore di von Willebrand Punto nel tempo (episodio) Studio di coagulazione |
zh-CN | Chinese (China) | von Willebrand 因子裂解蛋白酶活性: Synonyms: von Willebrand von Willebrand 因子(von Willebrand Factor, |
Example Units
Unit | Source |
---|---|
U/mL | Example UCUM Units |
LOINC Terminology Service (API) using HL7® FHIR® Get Info
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- CodeSystem lookup
- https:
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LOINC Copyright
Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright