93972-8Acetaminophen-cysteine adduct [Moles/volume] in Serum or PlasmaActive
Term Description
Acetaminophen-cysteine adduct (APAP-CYS) levels are measured in serum or plasma for the determination of liver injury due to acetaminophen-induced hepatotoxicity.[PMID: 27641661] The reactive metabolite of acetaminophen, N-acetyl-p-benzoquinone imine (NAPQI), is detoxified by glutathione at therapeutic doses. However, when glutathione is depleted, the metabolite covalently binds to cysteine groups on proteins and forms a acetaminophen-cysteine conjugate (3-(cystein-S-yl)-acetaminophen, APAP-CYS), which is thought to lead to hepatotoxicity.[PMID: 11901099]
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- Acetaminophen-cysteine adduct
- Property
- SCnc
- Time
- Pt
- System
- Ser/Plas
- Scale
- Qn
- Method
Additional Names
- Short Name
- APAP-Cysteine SerPl-sCnc
- Display Name
- Acetaminophen-cysteine adduct [Moles/Vol]
Basic Attributes
- Class
- DRUG/TOX
- Type
- Laboratory
- First Released
- Version 2.67
- Last Updated
- Version 2.67
- Order vs. Observation
- Both
Example Units
| Unit | Source |
|---|---|
| nmol/mL | Example UCUM Units |
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https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=93972-8
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