LOINC
Version 2.73

93972-8Acetaminophen-cysteine adduct [Moles/volume] in Serum or PlasmaActive

Part Description

LP412092-1   Acetaminophen-cysteine adduct
Acetaminophen-cysteine adduct (APAP-CYS) levels are measured in serum or plasma for the determination of liver injury due to acetaminophen-induced hepatotoxicity.[PMID:27641661] The reactive metabolite of acetaminophen, N-acetyl-p-benzoquinone imine (NAPQI), is detoxified by glutathione at therapeutic doses. However, when glutathione is depleted, the metabolite covalently binds to cysteine groups on proteins and forms a acetaminophen-cysteine conjugate (3-(cystein-S-yl)-acetaminophen, APAP-CYS), which is thought to lead to hepatotoxicity.[PMID:11901099] Source: LOINC, An Immunoassay to Rapidly Measure Acetaminophen Protein Adducts Accurately Identifies Patients With Acute Liver Injury or Failure

Fully-Specified Name

Component
Acetaminophen-cysteine adduct
Property
SCnc
Time
Pt
System
Ser/Plas
Scale
Qn
Method

Additional Names

Short Name
APAP-Cysteine SerPl-sCnc
Display Name
Acetaminophen-cysteine adduct [Moles/Vol]
Consumer Name Alpha
Acetaminophen-cysteine adduct, Blood

Basic Attributes

Class
DRUG/TOX
Type
Laboratory
First Released
Version 2.67
Last Updated
Version 2.72
Order vs. Observation
Both

Member of these Groups

LG51381-8 Acetaminophen-cysteine adduct|SCnc|Pt|ANYBldSerPl

Language Variants Get Info

zh-CNChinese (China)
对乙酰氨基酚-半胱氨酸加合物:物质的量浓度:时间点:血清/血浆:定量型:
fr-FRFrench (France)
Acétaminophène-cystéine adduit:Moles/Volume:Ponctuel:Sérum/Plasma:Numérique:
it-ITItalian (Italy)
Acetaminofene-cisteina, addotto:SCnc:Pt:Siero/Plasma:Qn:
es-MXSpanish (Mexico)
Aducto de acetaminofeno-cisteína:Concentración de sustancias:Punto temporal:Suero o Plasma:Cuantitativo:
es-ESSpanish (Spain)
Aducto de acetaminofeno-cisteína:Concentración de sustancia:Punto temporal:Suero o Plasma:Qn:

Example Units

Unit Source
nmol/mL Example UCUM Units

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=93972-8