93972-8Acetaminophen-cysteine adduct [Moles/volume] in Serum or PlasmaActive
Part Description
LP412092-1 Acetaminophen-cysteine adduct
Acetaminophen-cysteine adduct (APAP-CYS) levels are measured in serum or plasma for the determination of liver injury due to acetaminophen-induced hepatotoxicity.[PMID:27641661] The reactive metabolite of acetaminophen, N-acetyl-p-benzoquinone imine (NAPQI), is detoxified by glutathione at therapeutic doses. However, when glutathione is depleted, the metabolite covalently binds to cysteine groups on proteins and forms a acetaminophen-cysteine conjugate (3-(cystein-S-yl)-acetaminophen, APAP-CYS), which is thought to lead to hepatotoxicity.[PMID:11901099]
Source: LOINC, An Immunoassay to Rapidly Measure Acetaminophen Protein Adducts Accurately Identifies Patients With Acute Liver Injury or Failure
Fully-Specified Name
- Component
- Acetaminophen-cysteine adduct
- Property
- SCnc
- Time
- Pt
- System
- Ser/Plas
- Scale
- Qn
- Method
Additional Names
- Short Name
- APAP-Cysteine SerPl-sCnc
- Display Name
- Acetaminophen-cysteine adduct [Moles/Vol]
- Consumer Name Alpha
- Acetaminophen-cysteine adduct, Blood
Basic Attributes
- Class
- DRUG/TOX
- Type
- Laboratory
- First Released
- Version 2.67
- Last Updated
- Version 2.72
- Order vs. Observation
- Both
Member of these Groups
LG51381-8 | Acetaminophen-cysteine adduct| |
Language Variants Get Info
- zh-CNChinese (China)
- 对乙酰氨基酚-半胱氨酸加合物:
物质的量浓度: 时间点: 血清/血浆: 定量型: - fr-FRFrench (France)
- Acétaminophène-cystéine adduit:
Moles/Volume: Ponctuel: Sérum/Plasma: Numérique: - it-ITItalian (Italy)
- Acetaminofene-cisteina, addotto:
SCnc: Pt: Siero/Plasma: Qn: - es-MXSpanish (Mexico)
- Aducto de acetaminofeno-cisteína:
Concentración de sustancias: Punto temporal: Suero o Plasma: Cuantitativo: - es-ESSpanish (Spain)
- Aducto de acetaminofeno-cisteína:
Concentración de sustancia: Punto temporal: Suero o Plasma: Qn:
Example Units
Unit | Source |
---|---|
nmol/mL | Example UCUM Units |
LOINC FHIR® API Example - CodeSystem Request Get Info
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=93972-8
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