LOINC
Version 2.67

93972-8Acetaminophen-cysteine adduct [Moles/volume] in Serum or PlasmaActive

Term Description

Acetaminophen-cysteine adduct (APAP-CYS) levels are measured in serum or plasma for the determination of liver injury due to acetaminophen-induced hepatotoxicity.[PMID: 27641661] The reactive metabolite of acetaminophen, N-acetyl-p-benzoquinone imine (NAPQI), is detoxified by glutathione at therapeutic doses. However, when glutathione is depleted, the metabolite covalently binds to cysteine groups on proteins and forms a acetaminophen-cysteine conjugate (3-(cystein-S-yl)-acetaminophen, APAP-CYS), which is thought to lead to hepatotoxicity.[PMID: 11901099]
Source: Regenstrief LOINC

Fully-Specified Name

Component
Acetaminophen-cysteine adduct
Property
SCnc
Time
Pt
System
Ser/Plas
Scale
Qn
Method

Additional Names

Short Name
APAP-Cysteine SerPl-sCnc
Display Name
Acetaminophen-cysteine adduct [Moles/Vol]

Basic Attributes

Class
DRUG/TOX
Type
Laboratory
First Released
Version 2.67
Last Updated
Version 2.67
Order vs. Observation
Both

Example Units

Unit Source
nmol/mL Example UCUM Units

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=93972-8