LOINC
Version 2.71

94433-0HLA-DP and DQ and DR (class II) IgG with prozone effect [Identifier] in Serum or Plasma by Flow cytometry (FC)Active

Term Description

Sometimes high titer antibody can be associated with low levels of detection (low mean fluorescence intensity, MFI, for the Luminex HLA bead assay), a phenomenon often referred to as the "prozone" effect. This term is intended to report those antibodies that were not detected at significant level with original sample, but became detectable after dilution or assay treatment. Some laboratories refer to these "prozone antigens observed", meaning those antigens for which the patient's antibody exhibited prozone effect.
Source: Regenstrief LOINC

Part Descriptions

LP417655-0   HLA-DP & DQ & DR (class II) Ab.IgG with prozone effect
HLA antibodies showing the prozone effect represent antibody specificities against HLA antigens that were not apparent in undiluted patient specimen, but became apparent after dilution. This so called prozone effect has been attributed to a number of putative mechanisms, including complement factor, antibody agglutination or competing IgM. Prozone effect can often be reversed with serum dilution or treatment with heat, EDTA, or DTT. Source: Regenstrief LOINC

LP417655-0   HLA-DP & DQ & DR (class II) Ab.IgG with prozone effect
The major histocompatibility complex (MHC) class I (A, B, and C) and II (DP, DM, DOA, DOB, DQ, and DR) in the human leukocyte antigen (HLA) system contains a large number of genes involved in immune system function in humans. The proteins encoded by some genes form antigens. HLA class I and II antigens are widely distributed on all nucleated cells and carried by platelets.

Antibodies specific to HLA class I and II antigens can be acquired through alloimmunization due to pregnancy, transfusion of blood products, or previous transplants. Alloimmunization can lead to production of antibodies in approximately one third of individuals. The presence of antibodies, specifically IgG, can affect the survival of transplant allografts or transfused platelets in sensitized individuals. Various testing methods are used to detect antibodies to HLA antigens. Source: Regenstrief LOINC

Fully-Specified Name

Component
HLA-DP & DQ & DR (class II) Ab.IgG with prozone effect
Property
Prid
Time
Pt
System
Ser/Plas
Scale
Nom
Method
Flow cytometry

Additional Names

Short Name
HLA classII Ab.IgG prozone SerPl FC
Display Name
HLA-DP & DQ & DR (class II) Ab.IgG with prozone effect FC Nom
Consumer Name Alpha
HLA-DP & DQ & DR (class II) Ab.IgG with prozone effect, Blood

Example Answer List LL3602-1

Source: NCBI PubMed

Answer Code Score Answer ID
Anti-DP1 LA23895-8
Anti-DP2 LA23894-1
Anti-DP3 LA23897-4
Anti-DP4 LA23896-6
Anti-DP5 LA23898-2
Anti-DP6 LA23899-0
Anti-DQ1 LA23909-7
Anti-DQ2 LA23906-3
Anti-DQ3 LA23907-1
Anti-DQ4 LA23908-9
Anti-DQ5(1) LA23903-0
Anti-DQ6(1) LA23902-2
Anti-DQ7(3) LA23904-8
Anti-DQ8(3) LA23905-5
Anti-DR1 LA23910-5
Anti-DR3 LA23914-7
Anti-DR4 LA23915-4
Anti-DR6 LA23922-0
Anti-DR7 LA23916-2
Anti-DR8 LA23917-0
Anti-DR10 LA23918-8
Anti-DR11(5) LA23919-6
Anti-DR12(5) LA23920-4
Anti-DR13(6) LA23921-2
Anti-DR14(6) LA23923-8
Anti-DR15(2) LA23924-6
Anti-DR16(2) LA23925-3
Anti-DR17(3) LA23912-1
Anti-DR18(3) LA23913-9
Anti-DR51 LA23927-9
Anti-DR52 LA23926-1
Anti-DR53 LA23928-7
Anti-DR103 LA23911-3

Basic Attributes

Class
HLA
Type
Laboratory
First Released
Version 2.68
Last Updated
Version 2.68
Order vs. Observation
Observation

Member of these Panels

LOINC Long Common Name
94428-0 HLA class I and II IgG panel - Serum or Plasma by Flow cytometry (FC)
94440-5 HLA-DP and DQ and DR (class II) IgG panel - Serum or Plasma by Flow cytometry (FC)

Language Variants Get Info

zh-CNChinese (China)
HLA-DP 与 DQ 与 DR (II 类) 抗体.IgG 伴前带效应:存在与否或特征标识:时间点:血清/血浆:名义型:流式细胞测量术
nl-NLDutch (Netherlands)
HLA-DP & DQ & DR (klasse II) As.IgG met prozoneffect:identificator:moment:serum of plasma:nominaal:flowcytometrie
fr-FRFrench (France)
HLA-DP et DQ et DR (classe II) anticorps IgG avec effet prozone:Identification:Ponctuel:Sérum/Plasma:Résultat nominal:Cytométrie de flux
it-ITItalian (Italy)
HLA-DP & DQ & DR (classe II) Ab.IgG con effetto prozona:Prid:Pt:Siero/Plasma:Nom:Citometria a flusso
es-ESSpanish (Spain)
HLA-DP , DQ , DR (CLASE II) con efecto prozona por Ac IgG:Presencia o identidad:Punto temporal:Suero o Plasma:Nom:Citometria de flujo (FC)

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=94433-0