94442-1

HLA-A and B and C (class I) IgG with prozone effect [Identifier] in Serum or Plasma by Flow cytometry (FC)

Active

Term Description

Sometimes high titer antibody can be associated with low levels of detection (low mean fluorescence intensity, MFI, for the Luminex HLA bead assay), a phenomenon often referred to as the "prozone" effect. This term is intended to report those antibodies that were not detected with original sample, but became detectable after dilution or assay treatment. Some laboratories refer to these "prozone antigens observed", meaning those antigens for which the patient's antibody exhibited prozone effect.
Source: Regenstrief LOINC

Part Descriptions

LP417651-9 HLA-A & B & C (class I) Ab.IgG with prozone effect
HLA antibodies showing the prozone effect represent antibody specificities against HLA antigens that were not apparent in undiluted patient specimen, but became apparent after dilution. This so called prozone effect has been attributed to a number of putative mechanisms, including complement factor, antibody agglutination or competing IgM. Prozone effect can often be reversed with serum dilution or treatment with heat, EDTA, or DTT. Source: Regenstrief LOINC

LP417651-9 HLA-A & B & C (class I) Ab.IgG with prozone effect
The major histocompatibility complex (MHC) class I (A, B, and C) and II (DP, DM, DOA, DOB, DQ, and DR) in the human leukocyte antigen (HLA) system contains a large number of genes involved in immune system function in humans. The proteins encoded by some genes form antigens. HLA class I and II antigens are widely distributed on all nucleated cells and carried by platelets.

Antibodies specific to HLA class I and II antigens can be acquired through alloimmunization due to pregnancy, transfusion of blood products, or previous transplants. Alloimmunization can lead to production of antibodies in approximately one third of individuals. The presence of antibodies, specifically IgG, can affect the survival of transplant allografts or transfused platelets in sensitized individuals. Various testing methods are used to detect antibodies to HLA antigens. Source: Regenstrief LOINC

Fully-Specified Name

Component: HLA-A & B & C (class I) Ab.IgG with prozone effect
Property: Prid
Time: Pt
System: Ser/Plas
Scale: Nom
Method: Flow cytometry

Additional Names

Short Name: HLA class I Ab.IgG prozone SerPl FC
Display Name: HLA-A & B & C (class I) Ab.IgG with prozone effect FC Nom
Consumer Name Alpha Get Info: HLA-A & B & C (class I) Ab.IgG with prozone effect, Blood

Example Answer List: LL5520-3

Source: NCBI PubMed

Answer	Code	Score	Answer ID
Anti-A1			LA23858-6
Anti-A2			LA23859-4
Anti-A3			LA23860-2
Anti-A9			LA23861-0
Anti-A11			LA23863-6
Anti-A28			LA23864-4
Anti-A29			LA23865-1
Anti-B7			LA23870-1
Anti-B12			LA23872-7
Anti-B13			LA23873-5
Anti-B22			LA23876-8
Anti-B27			LA23877-6
Anti-B35			LA23878-4
Anti-B41			LA23880-0
Anti-Cw1			LA23886-7
Anti-Cw4			LA23888-3
Anti-Cw5			LA23889-1
Anti-Cw3			LA23890-9
Anti-Cw7			LA23892-5

Basic Attributes

Class: HLA
Type: Laboratory
First Released: Version 2.68
Last Updated: Version 2.68
Order vs. Observation: Observation

Member of these Panels

LOINC	Long Common Name
94428-0	HLA class I and II IgG panel - Serum or Plasma by Flow cytometry (FC)
94446-2	HLA-A and B and C (class I) IgG panel - Serum or Plasma by Flow cytometry (FC)

Language Variants Get Info

Tag	Language	Translation
es-ES	Spanish (Spain)	HLA-A, B, C (clase I) con efecto prozona por Ac IgG:Presencia o identidad:Punto temporal:Suero o Plasma:Nom:Citometria de flujo (FC)
es-MX	Spanish (Mexico)	HLA-A & B & C (clase I) Ab.IgG con efecto prozona:Presencia o identidad:Punto temporal:Suero o Plasma:Nominal:Citometría de flujo (FC)
fr-FR	French (France)	HLA-A et B et C (classe I) anticorps IgG avec effet prozone:Identification:Ponctuel:Sérum/Plasma:Résultat nominal:Cytométrie de flux
it-IT	Italian (Italy)	HLA-A & B & C (classe I) Ab.IgG con effetto prozona:Prid:Pt:Siero/Plasma:Nom:Citometria a flusso Synonyms: Citometria a flusso (FC) HLA tipizzazione tissutale antigeni-anticorpi HLA-A e B e C (classe I) HLA-Ae B e C (classe I) Ab.IgG con effetto prozona Plasma Presenza o Identità Punto nel tempo (episodio) Siero Siero o Plasma
nl-NL	Dutch (Netherlands)	HLA A & B & C (klasse I) As.IgG met prozoneffect:identificator:moment:serum of plasma:nominaal:flowcytometrie
pl-PL	Polish (Poland)	HLA-A & B & C (klasa I) Ab.IgG z efektem prozony:wykrycie lub identyfikacja:punkt w czasie:surowica lub osocze:cecha:cytometria przepływowa (FC) Synonyms: IgG Przeciwciała do antygenu I układu grupowego krwi Ii Przeciwciała IgG do HLA-A, B i C (klasa I) Przeciwciała IgG do HLA-A, B i C (klasa I) ze efektem prozony
zh-CN	Chinese (China)	HLA-A 与 B 与 C (I 类) 抗体.IgG 伴前带效应:存在与否或特征标识:时间点:血清/血浆:名义型:流式细胞测量术 Synonyms: A 型 A,B 型;AB 型 B 型 C 型;丙;丙型 HLA I 类;I 类 HLA HLA 抗原;人类白细胞抗原;human leukocyte antigen HLA-A 与 B 与 C (I 类) 抗体（Ab）.IgG 伴前带效应;人类白细胞抗原;人白细胞抗原;human leukocyte antigen;HLA I 型 I 型抗体人白细胞抗原人类白细胞抗原人类白细胞抗原（Human Leukocyte Antigen，HLA）人类白细胞抗原;人白细胞抗原;human leukocyte antigen;HLA 免疫球蛋白 G 分类型应答;分类型结果;名义性;名称型;名词型;名词性;标称性;没有自然次序的名义型或分类型应答动态存在;存在与否;特征标识;身份;身份标识族;种类;等;类;类别;级;纲;组时刻;随机;随意;瞬间流流式细胞光度计;流式细胞测量术（Flow Cytometry，FC）;流式细胞计白细胞抗原血清或血浆

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