LOINC
Version 2.73

94674-925-Hydroxyvitamin D3+25-Hydroxyvitamin D2/24,25-dihydroxyvitamin D3+24,25-dihydroxyvitamin D2 ratio panel in Serum or PlasmaActive

Term Description

Testing for an elevated ratio of 25HDN to 24,25 DHD can be used to reveal the likely presence of mutations in the CYP24A1 gene. CYP24A1 converts 25 hydroxyvitamin D to 24,25 dihydroxyvitamin D, a process thought to prevent overproduction of the active metabolite 1,25 dihydroxyvitamin D.
Source: Regenstrief LOINC

Part Descriptions

LP417249-2   Calcidiol+ercalcidiol/24r-Hydroxycalcidiol+24r-Hydroxyercalcidiol ratio panel
24,25-dihydroxyvitamin D (24,25 DHD), also known as 24r-Hydroxycalcidiol, is an INactive metabolite produced by alternative hydroxylation of 25 hydroxyvitamin D (25HDN) by the CYP24A1 enzyme. The hydroxylation by CYP24A1 competes with hydroxylation to active form 1,25-dihydroxyvitamin D (1,25 DHD) by the CYP27B1 enzyme, and is an important process that prevents overproduction of 1,25 DHD and resulting vitamin D toxicity. Testing for an elevated ratio of 25HDN to 24,25 DHD can be used to reveal the likely presence of mutations in the CYP24A1 gene [PMID:22648296]. Source: Regenstrief LOINC

LP182450-9   Calcidiol+ercalcidiol
The total of 25-hydroxyvitamin D3 (calcidiol) + 25-hydroxyvitamin D2 (ercalcidiol), which is often reported simply as 25-hydroxyvitamin D, or 25-OH-D. Source: Regenstrief LOINC

Panel Hierarchy
Details for each LOINC in Panel LHC-Forms

LOINC Name R/O/C Cardinality Example UCUM Units
94674-9 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2/24,25-dihydroxyvitamin D3+24,25-dihydroxyvitamin D2 ratio panel in Serum or Plasma
Indent94673-1 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2/24,25-dihydroxyvitamin D3+24,25-dihydroxyvitamin D2 [Mass Ratio] in Serum or Plasma {ratio}
Indent94672-3 24,25-dihydroxyvitamin D3+24,25-dihydroxyvitamin D2 [Mass/volume] in Serum or Plasma ng/mL
Indent49590-3 Calcidiol and Calciferol panel - Serum or Plasma
IndentIndent62292-8 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Mass/volume] in Serum or Plasma R ng/mL
IndentIndent1989-3 25-hydroxyvitamin D3 [Mass/volume] in Serum or Plasma R ng/mL
IndentIndent49054-0 25-hydroxyvitamin D2 [Mass/volume] in Serum or Plasma R ng/mL
IndentIndent49591-1 Calcidiol and Calciferol [Interpretation] in Serum or Plasma Narrative O

Fully-Specified Name

Component
Calcidiol+ercalcidiol/24r-Hydroxycalcidiol+24r-Hydroxyercalcidiol ratio panel
Property
-
Time
Pt
System
Ser/Plas
Scale
-
Method

Additional Names

Short Name
25D3+25D2/24,25D3+24,25D2 Pnl SerPl
Display Name
25-hydroxyvitamin D/24,25-dihydroxyvitamin D3+24,25-dihydroxyvitamin D2 ratio panel
Consumer Name Alpha
25-hydroxyvitamin D/24,25-dihydroxyvitamin D3+24,25-dihydroxyvitamin D2 ratio panel, Blood

Basic Attributes

Class
PANEL.CHEM
Type
Laboratory
First Released
Version 2.68
Last Updated
Version 2.68
Order vs. Observation
Order
Panel Type
Panel

Language Variants Get Info

zh-CNChinese (China)
钙二醇+羟基钙二醇/24r-羟基钙二醇+24r,25-羟基钙化醇比率组套:-:时间点:血清/血浆:-:
nl-NLDutch (Netherlands)
25-hydroxyvitamine D2 + 25-hydroxyvitamine D3/24,25-dihydroxyvitamine D3 + 24,25-dihydroxyvitamine D2 verhouding panel:-:moment:serum of plasma:-:
fr-FRFrench (France)
25-hydroxycholécalciférol+25-hydroxyergocalciférol/24r-hydroxycholécalciférol+24r-hydroxyergocalciférol panel:-:Ponctuel:Sérum/Plasma:-:
it-ITItalian (Italy)
25-Idrossivitamina D2+25-Idrossivitamina D3/24r-Idrossicalcidiolo+24r-Idrossicalcidiolo, panel rapporto:-:Pt:Siero/Plasma:-:
es-MXSpanish (Mexico)
Panel de relación calcidiol + ercalcidiol / 24r-Hydroxycalcidiol + 24r-Hydroxyercalcidiol:-:Punto temporal:Suero o Plasma:-:
es-ESSpanish (Spain)
25-Hidroxivitamina D2+25-Hidroxivitamina D3/Panel de proporción de 24,25-dihidroxivitamina D3 + 24,25-dihidroxivitamina D2:Propiedades mixtas (sólo paneles):Punto temporal:Suero o Plasma:-:

LOINC FHIR® API Example - CodeSystem and Questionnaire Requests Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=94674-9 https://fhir.loinc.org/Questionnaire/?url=http://loinc.org/q/94674-9