LOINC
Version 2.72

94718-4Alpha defensins 1+2+3 [Presence] in Synovial fluid by ImmunoassayActive

Term Description

Qualitative detection of human neutrophil peptide-1, -2, and -3, also known as alpha defensins 1-3, in synovial fluid by immunoassay methods, such as ELISA or lateral flow assay, for the diagnosis of periprosthetic joint infections (PJI). This assay detects but does not differentiate between the three HNP peptides. This term was created for, but not limited in use to, Zimmer Biomet Diagnostics Synovasure Alpha Defensin ELISA and Lateral Flow Test kits. The Synovasure Lateral flow test utilizes the same anti-microbial peptide as the ELISA test to detect the immune response to infection, but the Lateral Flow returns results in 10 minute whereas the ELISA typically has a 24-48 hour result turnaround.
Source: Regenstrief LOINC

Part Description

LP417746-7   Alpha defensins 1+2+3
Human neutrophil peptides (HNPs), also known as alpha defensins, are antimicrobial peptides released by activated neutrophils in response to infection. HNP-1 and HNP-2 are encoded by the DEFA1 gene, and HNP-3 is encoded by DEFA3 gene. All three peptides are nearly identical; they only differ by the first amino acid in their sequence. HNPs have antibacterial, fungicide and antiviral activities.[PMID:15616305] They have been extensively studied as a biomarker in various diseases such as infections, atherosclerosis, rheumatic diseases, preeclampsia, and cancer.[PMID:16513165][PMID:19186224][PMID:25196784] HNP synovial fluid proteins are used as a diagnostic biomarker for periprosthetic joint infection (PJI).[PMID:31856885] Source: Regenstrief LOINC

Fully-Specified Name

Component
Alpha defensins 1+2+3
Property
PrThr
Time
Pt
System
Synv fld
Scale
Ord
Method
IA

Additional Names

Short Name
Alpha defensins 1+2+3 Snv Ql IA
Display Name
Alpha defensins 1+2+3 IA Ql (Syn fld)
Consumer Name Alpha
Alpha defensins 1+2+3, Synovial fluid

Example Answer List LL2021-5

Source: Gen-Probe

Answer Code Score Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6
Invalid Copyright http://snomed.info/sct ID:455371000124106 Invalid result (qualifier value) LA15841-2

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.68
Last Updated
Version 2.72
Order vs. Observation
Both

Language Variants Get Info

zh-CNChinese (China)
Alpha 防御素 1+2+3:存在情况或阈值:时间点:滑液:序数型:免疫测定法
nl-NLDutch (Netherlands)
alfa-defensine 1 + 2 + 3:aanwezigheid:moment:synoviaal vocht:ordinaal:immunoassay
fr-FRFrench (France)
Alpha défensines 1+2+3:Présence/Seuil:Ponctuel:Liquide synovial:Qualitatif:Immunoanalyse
it-ITItalian (Italy)
Alfa defensine 1+2+3:PrThr:Pt:Liquido sinoviale:Ord:IA
es-MXSpanish (Mexico)
Alfa defensinas 1 + 2 + 3:Presencia o umbral:Punto temporal:Líquido sinovial:Ordinal:Inmunoensayo
es-ESSpanish (Spain)
Alfa defensinas 1+2+3:PrThr:Punto temporal:Líquido sinovial:Ord:IA

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=94718-4