LOINC
Version 2.73

94870-3Ganglioside GD1b IgM Ab [Presence] in Serum by ImmunoassayActive

Part Descriptions

LP14394-8   Ganglioside GD1b
Gangliosides are a family of molecules that are present throughout the body but especially prevalent in cells of the nervous system. Specific gangliosides are named for the carbohydrate sequence they contain and have a unique distribution within the nervous system. The oligosaccharide groups on gangliosides act as cell surface markers that play a role in cellular recognition and cell-to-cell communication, and they also act as specific receptors for certain pituitary glycoprotein hormones and certain bacterial protein toxins such as cholera toxin.
Anti-ganglioside antibodies, primarily IgG, are present in the sera from approximately 60% of patients with Guillain-Barré syndrome (GBS), and antibodies against different gangliosides are associated with different forms of GBS.
1. Antibodies against GD1a/GD1b and GD1b/GT1b complexes have been found in patients with more severe GBS requiring mechanical ventilation;
2. Antibodies against GM1 or those against GalNAc-GD1a have been associated with acute motor axonal neuropathy;
3. Anti-GQ1b antibodies are specifically associated with a variant of GBS called Fisher syndrome, which is characterized by ophthalmoplegia and ataxia.
Detection of specific markers early in the course of GBS may help guide the plan of care. [PMID:21214559] Source: Regenstrief LOINC, PMID: 2121455

LP222219-0   Ganglioside
A ganglioside molecule consists of a glycosphingolipid (ceramide and oligosaccharide) with one or more sialic acid residues linked to the sugar chain. Molecules with one sialic acid residue are called monosialogangliosides (GM), those with two are called disialogangliosides (GD), and those with three are trisialogangliosides (GT). Gangliosides without any sialic acid residues are called asialogangliosides, while those that do not have a ceramide N-acyl group are called lysogangliosides. The number that typically is included at the end of the name indicates the order in which the molecule was discovered. For example, GM2 is a ganglioside with one sialic acid residue that was the second GM to be identified. Source: Regenstrief LOINC

Fully-Specified Name

Component
Ganglioside GD1b Ab.IgM
Property
PrThr
Time
Pt
System
Ser
Scale
Ord
Method
IA

Additional Names

Short Name
GD1b Gangl IgM Ser Ql IA
Display Name
Ganglioside GD1b IgM IA Ql (S)
Consumer Name Alpha
Ganglioside GD1b IgM antibody, Blood

Example Answer List LL360-9

Source: Regenstrief Institute

Answer Code Score Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.68
Last Updated
Version 2.68
Order vs. Observation
Both

Member of these Panels

LOINC Long Common Name
82455-7 Ganglioside Ab panel - Serum

Member of these Groups

LG17197-1 Ganglioside GD1b Ab.IgM|PrThr|Pt|ANYBldSerPl

Language Variants Get Info

zh-CNChinese (China)
神经节苷脂 GD1b 抗体.IgM:存在情况或阈值:时间点:血清:序数型:免疫测定法
nl-NLDutch (Netherlands)
ganglioside GD1b As.IgM:aanwezigheid:moment:serum:ordinaal:immunoassay
et-EEEstonian (Estonia)
Gangliosiid GD1b antikehad.IgM:PrThr:Pt:S:Ord:IA
fr-BEFrench (Belgium)
Ganglioside GD1b Anticorps. IgM:PrThr:Temps ponctuel:Sérum:Ordinal:IA
fr-CAFrench (Canada)
Ganglioside GD1b , IgM:Présence-Seuil:Temps ponctuel:Sérum:Ordinal:IA
fr-FRFrench (France)
Ganglioside GD1b anticorps IgM:Présence/Seuil:Ponctuel:Sérum:Qualitatif:Immunoanalyse
it-ITItalian (Italy)
Ganglioside GD1b Ab.IgM:PrThr:Pt:Siero:Ord:IA
ru-RURussian (Russian Federation)
Ганглиозид GD1b Ат.IgM:PrThr:ТчкВрм:Сыв:Пор:IA
es-MXSpanish (Mexico)
Gangliósido GD1b Ab.IgM:Presencia o umbral:Punto temporal:Suero:Ordinal:Inmunoensayo
es-ESSpanish (Spain)
Gangliosido GD1b IgM:PrThr:Punto temporal:Suero:Ord:IA
tr-TRTurkish (Turkey)
Gangliozid GD1b Ab.IgM:MevcEşik:Zmlı:Ser:Srl:İA

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=94870-3