94870-3Ganglioside GD1b IgM Ab [Presence] in Serum by ImmunoassayActive
Part Descriptions
LP14394-8 Ganglioside GD1b
Gangliosides are a family of molecules that are present throughout the body but especially prevalent in cells of the nervous system. Specific gangliosides are named for the carbohydrate sequence they contain and have a unique distribution within the nervous system. The oligosaccharide groups on gangliosides act as cell surface markers that play a role in cellular recognition and cell-to-cell communication, and they also act as specific receptors for certain pituitary glycoprotein hormones and certain bacterial protein toxins such as cholera toxin.
Anti-ganglioside antibodies, primarily IgG, are present in the sera from approximately 60% of patients with Guillain-Barré syndrome (GBS), and antibodies against different gangliosides are associated with different forms of GBS.
1. Antibodies against GD1a/GD1b and GD1b/GT1b complexes have been found in patients with more severe GBS requiring mechanical ventilation;
2. Antibodies against GM1 or those against GalNAc-GD1a have been associated with acute motor axonal neuropathy;
3. Anti-GQ1b antibodies are specifically associated with a variant of GBS called Fisher syndrome, which is characterized by ophthalmoplegia and ataxia.
Detection of specific markers early in the course of GBS may help guide the plan of care. [PMID:21214559]
Source: Regenstrief LOINC, PMID: 2121455
LP222219-0 Ganglioside
A ganglioside molecule consists of a glycosphingolipid (ceramide and oligosaccharide) with one or more sialic acid residues linked to the sugar chain. Molecules with one sialic acid residue are called monosialogangliosides (GM), those with two are called disialogangliosides (GD), and those with three are trisialogangliosides (GT). Gangliosides without any sialic acid residues are called asialogangliosides, while those that do not have a ceramide N-acyl group are called lysogangliosides. The number that typically is included at the end of the name indicates the order in which the molecule was discovered. For example, GM2 is a ganglioside with one sialic acid residue that was the second GM to be identified.
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- Ganglioside GD1b Ab.IgM
- Property
- PrThr
- Time
- Pt
- System
- Ser
- Scale
- Ord
- Method
- IA
Additional Names
- Short Name
- GD1b Gangl IgM Ser Ql IA
- Display Name
- Ganglioside GD1b IgM IA Ql (S)
- Consumer Name Alpha
- Ganglioside GD1b IgM antibody, Blood
Example Answer List LL360-9
Source: Regenstrief Institute
Answer | Code | Score | Answer ID |
---|---|---|---|
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) | LA6576-8 | ||
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) | LA6577-6 |
Basic Attributes
- Class
- SERO
- Type
- Laboratory
- First Released
- Version 2.68
- Last Updated
- Version 2.68
- Order vs. Observation
- Both
Member of these Panels
LOINC | Long Common Name |
---|---|
82455-7 | Ganglioside Ab panel - Serum |
Member of these Groups
LG17197-1 | Ganglioside GD1b Ab.IgM| |
Language Variants Get Info
- zh-CNChinese (China)
- 神经节苷脂 GD1b 抗体.IgM:
存在情况或阈值: 时间点: 血清: 序数型: 免疫测定法 - nl-NLDutch (Netherlands)
- ganglioside GD1b As.IgM:
aanwezigheid: moment: serum: ordinaal: immunoassay - et-EEEstonian (Estonia)
- Gangliosiid GD1b antikehad.IgM:
PrThr: Pt: S: Ord: IA - fr-BEFrench (Belgium)
- Ganglioside GD1b Anticorps. IgM:
PrThr: Temps ponctuel: Sérum: Ordinal: IA - fr-CAFrench (Canada)
- Ganglioside GD1b , IgM:
Présence-Seuil: Temps ponctuel: Sérum: Ordinal: IA - fr-FRFrench (France)
- Ganglioside GD1b anticorps IgM:
Présence/Seuil: Ponctuel: Sérum: Qualitatif: Immunoanalyse - it-ITItalian (Italy)
- Ganglioside GD1b Ab.IgM:
PrThr: Pt: Siero: Ord: IA - ru-RURussian (Russian Federation)
- Ганглиозид GD1b Ат.IgM:
PrThr: ТчкВрм: Сыв: Пор: IA - es-MXSpanish (Mexico)
- Gangliósido GD1b Ab.IgM:
Presencia o umbral: Punto temporal: Suero: Ordinal: Inmunoensayo - es-ESSpanish (Spain)
- Gangliosido GD1b IgM:
PrThr: Punto temporal: Suero: Ord: IA - tr-TRTurkish (Turkey)
- Gangliozid GD1b Ab.IgM:
MevcEşik: Zmlı: Ser: Srl: İA
LOINC FHIR® API Example - CodeSystem Request Get Info
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=94870-3
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LOINC Copyright
Copyright © 2022 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright