LOINC
Version 2.73

95272-1Aquaporin 4 water channel IgG Ab [Presence] in Serum by Cell binding immunofluorescent assayActive

Part Descriptions

LP39188-5   Aquaporin 4 water channel Ab.IgG
The water channel aquaporin 4 (AQP4) receptor regulates the water homeostasis in the central nervous system (CNS). Autoantibodies to the AQP4 receptor bind to the receptor and cause neuromyelitis optica (NMO) which is an idiopathic, severe, demyelinating disease of the CNS that primarily affects the optic nerve and spinal cord. Before the discovery of the AQP4 receptor antibody NMO was often misdiagnosed as a variant of multiple sclerosis (MS). With improved clinical laboratory tests and distinct immunological and pathological attributes the two diseases are less often confused. Distinguishing MS and NMO is especially important because they have different treatments. Treatment for NMO includes corticosteroids and plasmapheresis; typical medications used to treat MS, such as beta-interferon and glatiramer acetate are not effective against NMO. During the disease process, the aquaporin 4 receptor antibody binds to the aquaporin 4 receptor initiating the activation of complement, inflammatory demyelination and necrosis. Eighty to ninety percent of patients with NMO experience recurrent episodes of optic neuritis and myelitis. Many patients with NMO also have other autoimmune diseases including thyroiditis, systemic lupus erythematosus
and Sjogren's syndrome.[PMID:17706564] Detection of APQ4-IgG is indicative of a relapsing disease. Immediate treatment with immunosuppressive drugs reduces the frequency and disability of future attacks. [http://labmed.ucsf.edu/labmanual/db/dataall/tests/1424.html] Source: Regenstrief LOINC

LP269367-1   CBA IFA
In cell binding assays or cell-based assays (CBA) also known as cell-based immunoassays, the DNA coding for a particular antigen is transfected into cultured cells, which are then used directly as substrate for antibody detection by immunofluorescence. The advantage of CBA IFA over conventional immunoassays is that purification and stability of the antigen is not required and they provide an in vivo substrate. Source: Regenstrief LOINC

Fully-Specified Name

Component
Aquaporin 4 water channel Ab.IgG
Property
PrThr
Time
Pt
System
Ser
Scale
Ord
Method
CBA IFA

Additional Names

Short Name
AQP4 H2O channel IgG Ser Ql CBA IFA
Display Name
Aquaporin 4 water channel IgG Cell binding immunofluorescent assay Ql (S)
Consumer Name Alpha
Aquaporin 4 water channel IgG antibody, Blood

Example Answer List LL360-9

Source: Regenstrief Institute

Answer Code Score Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.68
Last Updated
Version 2.69
Order vs. Observation
Both

Member of these Groups

LG17408-2 Aquaporin 4 water channel Ab.IgG|PrThr|Pt|ANYBldSerPl

Language Variants Get Info

zh-CNChinese (China)
水通道蛋白 4 受体 抗体.IgG:存在情况或阈值:时间点:血清:序数型:CBA IFA
fr-FRFrench (France)
Aquaporine 4 récepteur anticorps IgG:Présence/Seuil:Ponctuel:Sérum:Qualitatif:Immunofluorescence CBA
it-ITItalian (Italy)
Acquaporina 4, canale idrico Ab.IgG:PrThr:Pt:Siero:Ord:CBA IFA
es-MXSpanish (Mexico)
Acuaporina 4 canal de agua Ab.IgG:Presencia o umbral:Punto temporal:Suero:Ordinal:Ensayo inmunofluorescente de unión a células
es-ESSpanish (Spain)
Receptor de Acuaporina 4 IgG:PrThr:Punto temporal:Suero:Ord:CBA IFA (inmunofluorescencia indirecta de estudio basqado en células)

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=95272-1