LOINC
Version 2.73

96365-2Naltrexol [Presence] in Saliva (oral fluid) by Confirmatory methodActive

Part Descriptions

LP199601-8   Naltrexol
Naltrexol has two forms: 6-beta naltrexol and 6-alpha naltrexol. 6-Beta naltrexol (6β-Naltrexol) is the major urinary metabolite of Naltrexone in man and has a significant pharmacological activity and a longer elimination half-life than the parent drug. [PMID:9248940] Naltrexone is an opioid antagonist used primarily in the management of alcohol dependence and opioid dependence. Relative to naltrexone, 6β-naltrexol has about half the affinity for the μ-opioid receptor, but is present at approximately 10-30-fold higher concentrations at steady state due to extensive first-pass metabolism of the parent drug. Source: Regenstrief LOINC, 6β-Naltrexol

LP7565-7   Saliva
Saliva is produced primarily by the parotid, submaxillary, and sublingual glands. It is secreted at the rate of 0-3 milliliters per minute which is affected by various factors including anxiety, hydration and hunger. Oral fluid is broadly used to test for drugs of abuse in employment and forensic settings, and is especially useful since it is difficult to adulterate, is quick and is non-invasive. Oral fluid is used to test a variety of analytes, including to test alcohol, HIV and other antibodies, therapeutic drugs and steroids, but its primary use is to test for drugs of abuse including amphetamines, cocaine and metabolites, opioids, methadone, cannabis and heroin.[PMID:17268583] Source: Regenstrief LOINC

LP262420-5   Saliva DRUG/TOX
Oral fluid (or saliva) is produced primarily by the parotid, submaxillary, and sublingual glands. It is secreted at the rate of 0-3 milliliters per minute which is affected by various factors including anxiety, hydration and hunger. Oral fluid is broadly used to test for drugs of abuse in employment and forensic settings, and is especially useful since it is difficult to adulterate, is quick and is non-invasive. Oral fluid is used to test a variety of analytes, including to test alcohol, HIV and other antibodies, therapeutic drugs and steroids, but its primary use is to test for drugs of abuse including amphetamines, cocaine and metabolites, opioids, methadone, cannabis and heroin. The test procedures that use oral fluid for drug screening are usually similar to those for other specimens but adapted for oral fluid. Oral fluid is broadly used to test for drugs of abuse in employment and forensic settings, and is especially useful since it is difficult to adulterate, is quick and is non-invasive. Drugs present in oral fluid are often the parent drug rather than a metabolite and tests kits reflect those differences. Concentrations of cocaine, amphetamines and some opioids in oral fluid are either similar or higher than concentrations in plasma. The concentration of tetrahydrocannabinol (THC) in oral fluid is similar to that of plasma, though in cases where recent ingestion has occurred, levels may be higher due to the significant local absorption in the oral cavity. Confirmatory testing on oral fluid using liquid chromatography-mass spectrometry (LC-MS) is highly sensitive and specific even on relatively small sample sizes. An increased understanding of pharmacokinetics in oral fluid has flourished inover the last ten years has allowed the correlation of . As a result, the concentrations of various drugs in oral fluid have been correlated to blood concentrations and the effects they have on the individual.[PMID:17268583] Source: Regenstrief LOINC

Fully-Specified Name

Component
Naltrexol
Property
PrThr
Time
Pt
System
Saliva
Scale
Ord
Method
Confirm

Additional Names

Short Name
Naltrexol Sal Ql Cfm
Display Name
Naltrexol Confirm Ql (Sal)
Consumer Name Alpha
Naltrexol, Saliva

Example Answer List LL360-9

Source: Regenstrief Institute

Answer Code Score Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Basic Attributes

Class
DRUG/TOX
Type
Laboratory
First Released
Version 2.69
Last Updated
Version 2.69
Order vs. Observation
Both

Member of these Groups

LG51065-7 Naltrexol|ANYProp|ANYTm|ANYSys|ANYMeth

Language Variants Get Info

zh-CNChinese (China)
纳曲醇:存在情况或阈值:时间点:唾液:序数型:毒理学确认试验
nl-NLDutch (Netherlands)
naltrexol:aanwezigheid:moment:speeksel:ordinaal:bevestiging
fr-FRFrench (France)
Naltréxol:Présence/Seuil:Ponctuel:Salive:Qualitatif:Confirmation
it-ITItalian (Italy)
Naltrexone:PrThr:Pt:Saliva:Ord:Conferma
es-MXSpanish (Mexico)
Naltrexol:Presencia o umbral:Punto temporal:Saliva:Ordinal:Confirmar
es-ESSpanish (Spain)
Naltrexol:PrThr:Punto temporal:Saliva:Ord:Confirmatorio
tr-TRTurkish (Turkey)
Naltrekzol:MevcEşik:Zmlı:Tükürük:Srl:Onay

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=96365-2