LOINC
Version 2.70

97503-7Abnormal Prion Protein [Presence] in Cerebral spinal fluidActive

Term Description

Detection of pathologic prions in cerebrospinal fluid (CSF). The submitter's test uses recombinant prion protein (PrP) as a reagent substrate and patient CSF in a real-time quaking-induced conversion (RT-QuIC) assay. If pathologic prions are present in the patient’s CSF, they propagate misfolding of the reagent PrP to form amyloid, which is detected using a fluorescent indicator. RT-QuIC has been adopted in clinical practice due to the sensitivity, specificity, and use of CSF (not a brain biopsy) for testing. The submitter's reported sensitivity of RT-QuIC in detecting CJD is >90%, and the specificity approaches 100%.
Source: Regenstrief LOINC

Part Description

LP35078-2   Prion protein.abnormal
Transmissible spongiform encephalopathies (TSEs), also known as prion diseases, are a group of progressive conditions (encephalopathies) that affect the brain and nervous system of many animals, including humans. According to the most widespread hypothesis they are transmitted by abnormal prions, though some other data suggest an involvement of a Spiroplasma infection. Mental and physical abilities deteriorate and a myriad of tiny holes appear in the cortex causing it to appear like a sponge (hence spongiform) when brain tissue obtained at autopsy is examined under a microscope. The disorders cause impairment of brain function, including memory changes, personality changes and problems with movement that worsen over time. Most TSEs are sporadic and occur in animals. Prion diseases of animals in include classical bovine spongiform encephalopathy (BSE) (C-type), atypical (H or L-type) BSE, Scrapie, atypical scrapie, Nor98, and chronic wasting disease (CWE). H-type and L-type BSE were named based on abnormal prion bands migrating to a higher (H) or lower (L) position on western blot analysis compared to the classical BSE (C-type) prion protein. Prion diseases of humans include classic Creutzfeldt–Jakob disease, new variant Creutzfeldt–Jakob disease (nvCJD, a human disorder related to Bovine spongiform encephalopathy), Gerstmann–Sträussler–Scheinker syndrome, fatal familial insomnia and kuru. These conditions form a spectrum of diseases with overlapping signs and symptoms. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Transmissible spongiform encephalopathy

Fully-Specified Name

Component
Prion protein.abnormal
Property
PrThr
Time
Pt
System
CSF
Scale
Ord
Method

Additional Names

Short Name
Abn Prion Prot CSF Ql
Display Name
Abnormal Prion Protein Ql (CSF)
Consumer Name Alpha
Abnormal prion protein, Spinal fluid

Example Answer List LL2038-9

Source: Quest Diagnostics Inc.

Answer Code Score Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6
Indeterminate Copyright http://snomed.info/sct ID:82334004 Indeterminate (qualifier value) LA11884-6

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.70
Last Updated
Version 2.70
Order vs. Observation
Both

Member of these Panels

LOINC Long Common Name
97502-9 Prion disease biomarker panel - Cerebral spinal fluid

Language Variants Get Info

zh-CNChinese (China)
朊病毒蛋白.异常:存在情况或阈值:时间点:脑脊液:序数型:
nl-NLDutch (Netherlands)
prioneiwit.abnormaal:aanwezigheid:moment:liquor cerebrospinalis:ordinaal:
fr-BEFrench (Belgium)
Protéines prion.anormales:PrThr:Temps ponctuel:LCR:Ordinal:
fr-CAFrench (Canada)
Protéines prion.anormales:Présence-Seuil:Temps ponctuel:LCR:Ordinal:
it-ITItalian (Italy)
Proteina prionica.anormale:PrThr:Pt:LCS:Ord:
ru-RURussian (Russian Federation)
Прионный протеин.аномальный:PrThr:ТчкВрм:ЦСЖ:Пор:
es-ESSpanish (Spain)
Proteína priónica anormal:PrThr:Punto temporal:Líquido Cefalorraquideo:Ord:
tr-TRTurkish (Turkey)
Prion protein.anormal:MevcEşik:Zmlı:BOS:Srl:

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=97503-7