LOINC
Version 2.72

98066-4Colistin resistance mcr-3+mcr-4+mcr-5 genes [Presence] by Molecular methodActive

Term Description

Qualitative detection of nucleic acids within the mobilized colistin resistance (mcr) genes 3-5 (mcr-3, mcr-4, mcr-5) found in Gram-negative bacteria. Testing may be performed in addition to conventional culture susceptibility testing to determine the potential bacterial resistance mechanism to antibiotics.
Source: Regenstrief LOINC

Part Description

LP426517-1   Bacterial colistin resistance mcr-3+mcr-4+mcr-5 genes
The mobilized colistin resistance genes (mcr-1 to mcr-5, and variants) are located on a plasmid within bacterial cells and affect the ability of antibiotics, including polymyxins and colistin, to bind to the bacteria. The mode of action of the antibiotics is to bind to the outer membrane of the phosphate group of lipid A lipopolysaccharide and to intercalate into the inner membrane forming pores that result in bacterial lysis. The polymyxins & colistin are the last line of defense used to treat multidrug resistant gram-negative bacteria so the emergence of the mcr genes in Enterobacteriaceae, including Klebsiella pneumoniae, is onerous and challenging to public health.[PMID:27893854][PMID:29439754] Source: Regenstrief LOINC

Fully-Specified Name

Component
Bacterial colistin resistance mcr-3+mcr-4+mcr-5 genes
Property
PrThr
Time
Pt
System
Isolate/Specimen
Scale
Ord
Method
Molgen

Additional Names

Short Name
Colistin res mcr-(3-5) Islt/Spm Ql
Display Name
Colistin resistance mcr-3+mcr-4+mcr-5 genes Molgen Ql (Islt/Spec)
Consumer Name Alpha
Colistin resistance mcr-3+mcr-4+mcr-5 genes

Example Answer List LL2021-5

Source: Gen-Probe

Answer Code Score Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6
Invalid Copyright http://snomed.info/sct ID:455371000124106 Invalid result (qualifier value) LA15841-2

Basic Attributes

Class
ABXBACT
Type
Laboratory
First Released
Version 2.70
Last Updated
Version 2.72
Order vs. Observation
Observation

Language Variants Get Info

zh-CNChinese (China)
细菌粘菌素耐药 mcr-3+mcr-4+mcr-5 基因:存在情况或阈值:时间点:分离株/标本:序数型:分子遗传学类实验室方法
nl-NLDutch (Netherlands)
bacteriële colistineresistentie mcr-3+mcr-4+mcr-5-genen:aanwezigheid:moment:isolaat of monster:ordinaal:moleculair genetisch onderzoek
it-ITItalian (Italy)
Geni mcr-3+mcr-4+mcr-5 di resistenza batterica alla colistina:PrThr:Pt:Isolato/Campione:Ord:Molgen
es-MXSpanish (Mexico)
Resistencia a la colistina bacteriana genes mcr-3 + mcr-4 + mcr-5:PrThr:Punto temporal:Aislar / Muestra:Ordinal:Molgen
es-ESSpanish (Spain)
genes bacterianos mcr-3 + mcr-4 + mcr-5 resistentes a colistina:PrThr:Punto temporal:Muestra aislada:Ord:Genética molecular

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=98066-4