99117-4
Toscana virus neutralizing antibody [Titer] in Specimen by Neutralization test
Active
Part Descriptions
LP190786-6 Toscana virus
Toscana virus (TOSV) was identified in 1971 in central Italy from sandflies Phlebotomus perniciosus and Phlebotomus perfiliewi PMID: 24175218. TOSV belongs to the family Phenuiviridae, genus Phlebovirus [NCBI Taxonomy: 11590)]. TOSV is a serotype of the species Sandfly fever Naples virus PMID: 24175218. TOSV is the only neurotropic sandfly phlebovirus typically causing meningitis and encephalitis. Additional neuroinvasive manifestations such as Guillain-Barré syndrome, hydrocephalus, myositis, fasciitis, polymyeloradiculopathy, deafness, and facial paralysis, have been reported. Toscana virus broadly circulates in in European Mediterranean basin and Northern Africa PMID: 32878929.
Source: Regenstrief LOINC
LP190786-6 Toscana virus
The Toscana virus (TOSV) belongs to the Bunyaviridae family whose genome is made of three negative single-stranded RNA segments. There are two genotypes of TOSV: A, found mainly in Italy, and B, occurring mainly in Spain. The distribution of the two genotypes may indicate the involvement of different vectors. Infection by TOSV is most prevalent in Italy and Spain in the summer months, though the geographical region where TOSV is expanding includes other countries in the Mediterranean basin. TOSV is transmitted to humans by the Phlebotomus species of sandflies. Though the animal reservoir has not been identified, TOSV has been isolated from the brain of a bat, which raises the question of it possibly being a host to the virus. TOSV causes aseptic meningitis in 95% of the people it infects, meningoencephalitis in 4.5% of those infected, and an influenza-like illness in the remaining .5% who are infected. Recently, unusual symptoms associated with TOSV have included ischemic complications and hydrocephalus. TOSV is emerging as an important pathogen as its distribution increases due to changes in the climate, globalization and habitat modification. Other than supportive therapy, there is no treatment for infection with TOSV. PMID: 20517492
Source: Regenstrief LOINC
LP207365-0 Ab.Neut
Neutralizing antibodies are antibodies that interfere with the interaction between the virus and its host cell receptor, therefore preventing infectivity. Neutralizing antibodies can be detected using a traditional VNT or other methods such as pseudovirus VNT and surrogate VNT. VNT and pseudovirus VNT use live virus (the actual virus or a recombinant virus that incorporates the viral antigen of interest, respectively) and cell culture to assess the virus-host interaction and whether neutralizing antibodies are present that block that interaction. Surrogate VNT (sVNT) does not use live virus but rather uses purified viral antigen and host cell receptor protein to mimic the same interaction. The sVNT method is currently (2021) represented in LOINC as IA, because it is an immunoassay-based method.
Source: Regenstrief LOINC
LP6416-4 Neut
In LOINC, the Method "Neut" represents the virus neutralization test (VNT), also called conventional VNT, which is a specific laboratory method that is used primarily for identifying whether neutralizing antibodies for the virus of interest are present in the patient sample. The VNT involves incubating patient serum with the virus of interest, and then inoculating onto cell culture. If neutralizing antibodies are present and the virus is neutralized, the cells will not be infected. If neutralizing antibodies are not present, the virus will infect the cells in the cell culture. PMID: 32170698 This method can also be used to identify specific virus serotypes or strains, by performing separate tests in which serum is incubated with each of the specific virus serotypes or strains of interest. PMID: 169804
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- Toscana virus Ab.Neut
- Property
- Titr
- Time
- Pt
- System
- XXX
- Scale
- SemiQn
- Method
- Neut
Additional Names
- Short Name
- TOSV NAb Titr Spec Nt
- Display Name
- Toscana virus neut ab Neut test (Specimen) [Titer]
- Consumer Name Alpha Get Info
- Toscana virus neutralizing antibody, Specimen
Basic Attributes
- Class
- MICRO
- Type
- Laboratory
- First Released
- Version 2.72
- Last Updated
- Version 2.75
- Order vs. Observation
- Both
Language Variants Get Info
Tag | Language | Translation |
---|---|---|
es-ES | Spanish (Spain) | Virus Toscana Anticuerpos antineutrófilos: Synonyms: Semicuantitativo |
fr-FR | French (France) | Toscana virus Ac neutralisant: |
it-IT | Italian (Italy) | Virus Toscana Ab.Neut: Synonyms: anticorpo Microbiologia Punto nel tempo (episodio) Test di neutralizzazione Titolo |
nl-NL | Dutch (Netherlands) | Toscana virus As.neutraliserend: Synonyms: antistof; |
pl-PL | Polish (Poland) | Wirus gorączki wywołanej przez muchę piaskową typ toskański Ab.Neutralizujące: Synonyms: Przeciwciała do toskańskiego typu wirusa gorączki wywołanej przez muchę piaskową Przeciwciała neutralizujące do toskańskiego typu wirusa gorączki wywołanej przez muchę piaskową Toskański typ wirusa gorączki wywołanej przez muchę piaskową |
zh-CN | Chinese (China) | 托斯卡纳病毒 抗体.中和: Synonyms: Ab; |
Example Units
Unit | Source |
---|---|
{titer} | Example UCUM Units |
LOINC Terminology Service (API) using HL7® FHIR® Get Info
Requests to this service require a free LOINC username and password. Below is a sample of the possible capabilities. See the LOINC Terminology Service documentation for more information.
- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=99117-4
LOINC Copyright
Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright