LOINC
Version 2.73

99308-9Acid alpha glucosidase cross-reactive immunologic material (CRIM) [Presence] in Leukocytes by ImmunoblotActive

Term Description

Cross-reactive immunological material (CRIM) status in patients with Pompe disease is important when assessing whether immunosuppression is needed when initiating enzyme replacement therapy.
Source: Regenstrief LOINC

Part Description

LP429267-0   Acid alpha glucosidase cross-reactive immunologic material (CRIM)
Pompe disease (also known as glycogen storage disease type II and acid maltase deficiency) is an autosomal recessive disorder caused by a deficiency of the lysosomal enzyme acid α-glucosidase (GAA). Prompt diagnosis and initiation of enzyme replacement therapy with recombinant human GAA (rhGAA) are critical for reducing mortality and disability. A key predictor of clinical response to replacement therapy is a patient's CRIM (cross-reactive immunological material to GAA) status, which is based on the presence or absence of endogenous GAA. Patients who are CRIM-positive produce detectable GAA and are typically immunologically tolerant of rhGAA, whereas approximately 20% of patients who are CRIM-negative develop high levels of antibodies against exogenous rhGAA, which eventually reduces the efficacy of therapy [PMID:24044919]. Source: Regenstrief LOINC

Fully-Specified Name

Component
Acid alpha glucosidase cross-reactive immunologic material (CRIM)
Property
PrThr
Time
Pt
System
WBC
Scale
Ord
Method
IB

Additional Names

Short Name
AAG CRIM WBC Ql IB
Display Name
Acid alpha glucosidase cross-reactive immunologic material (CRIM) IB Ql (WBC)
Consumer Name Alpha
Acid alpha glucosidase cross-reactive immunologic material (CRIM), White blood cells

Example Answer List LL360-9

Source: Regenstrief Institute

Answer Code Score Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.72
Last Updated
Version 2.72
Order vs. Observation
Both

Language Variants Get Info

zh-CNChinese (China)
酸性 alpha 葡萄糖苷酶交叉反应免疫物质:存在情况或阈值:时间点:白细胞:序数型:免疫印迹法
it-ITItalian (Italy)
Alfa-glucosidasi acida materiale immunologico cross-reattivo (CRIM):PrThr:Pt:WBC:Ord:IB
es-ESSpanish (Spain)
Material inmunológico de reacción cruzada con alfa glucosidasa ácida (CRIM):PrThr:Punto temporal:Células sanguineas blancas:Ord:Inmunoblot (IB)

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=99308-9