99439-2
Cashew nut recombinant (rAna o) 3 IgG4 Ab [Mass/volume] in Serum
Active
Part Descriptions
LP220394-3 Anacardium occidentale recombinant (rAna o) 3
Anacardium occidentale (Ana o) 3 is a 2S albumin and a major allergen of cashew nuts that elicits an allergic response in 81% of people with a sensitivity to cashews. 2S albumins have a very stable intrinsic structure that is preserved even in harsh environments, such as the gastrointestinal tract where it is believed to initiate an immune response. Due to its resistance to both hydrolysis in the intestinal tract and denaturation by heat, Ana o 3 is considered a very potent allergen.(http://www.phadia.com/es/5/Productos/ImmunoCAP-Allergens/Food-of-Plant-Origin/Allergen-Components/rAna-o-3-Cashew-nut/) Three native large subunit isoforms of recombinant Ana o 3 have been identified to have 16 reactive peptides, four of which produce strong signals. One isoform shares a fair amount of homology with a walnut isoform and offers a basis for cross-reactivity of walnut with the Ana o 3 isotope. PMID: 15940148
Source: Regenstrief LOINC
LP32397-9 Ab.IgG4
IgG4 is the least common subtype of IgG, and it has a variety of functions. In the context of allergic disease it is thought to have an immune-inhibitory role in preventing anaphylaxis and is commonly known as a "blocking" antibody. IgG4 binding to an allergen can compete with IgE-mediated binding, thereby inhibiting the activation of mast cells and basophils and IgE-mediated presentation to T-cells. Measuring IgG4 and its ratio to IgE has a role in monitoring allergen specific immunotherapy PMID: 26023323. IgG4 is also thought to have a role in autoimmunity and be involved in a less defined entity known as IgG4-Related Disease, a chronic immune-mediated fibroinflammatory disorder that often manifests with tumor-like masses .[https://www.merckmanuals.com/professional/musculoskeletal-and-connective-tissue-disorders/igg4-related-disease/igg4-related-disease]
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- Anacardium occidentale recombinant (rAna o) 3 Ab.IgG4
- Property
- MCnc
- Time
- Pt
- System
- Ser
- Scale
- Qn
- Method
Additional Names
- Short Name
- Cashew nut (rAna o) 3 IgG4-mCnc
- Display Name
- Cashew nut recombinant (rAna o) 3 IgG4 (S) [Mass/Vol]
- Consumer Name Alpha Get Info
- Cashew nut recombinant (rAna o) 3 IgG4 antibody
Basic Attributes
- Class
- ALLERGY
- Type
- Laboratory
- First Released
- Version 2.72
- Last Updated
- Version 2.72
- Order vs. Observation
- Both
Language Variants Get Info
Tag | Language | Translation |
---|---|---|
es-ES | Spanish (Spain) | Recombimante rAna o 3. Cashew nut (Anacardium occidentale) IgG4: Synonyms: Cuantitativo |
fr-FR | French (France) | Noix de cajou rAna o3 (recombinant) Ac IgG4: |
it-IT | Italian (Italy) | Anacardium occidentale, ricombinante (rAna o) 3 Ab.IgG4: Synonyms: Anacardio (Anacardium occidentale) Anticorpi IgG4 anticorpo Concentrazione di Massa Punto nel tempo (episodio) Ricombinante (rAna o) 3 di anacardio (Anacardium o Risposta agli antigeni Siero |
nl-NL | Dutch (Netherlands) | cashewnoot (Anacardium occidentale) recombinant (rAna o) 3 As.IgG4: Synonyms: antistof; |
pl-PL | Polish (Poland) | Anacardium occidentale rekombinowany (rAna o) 3 Ab.IgG4: Synonyms: Nanercz zachodni (anacardium occidentale) Przeciwciała IgE do komponenty alergenowej Ana o 3 orzecha nanercza zachodniego (anacardium occidentale) |
zh-CN | Chinese (China) | 腰果 重组 (rAna o) 3 抗体.IgG4: Synonyms: Ⅲ Ab.IgG4; |
Example Units
Unit | Source |
---|---|
mg/L | Example UCUM Units |
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