LA26399-8
Oligo aCGH
Active
Answer Description
The use of dense arrays of oligonucleotides deposited on glass slides, subjected to fluorescent Comparative Genomic Hybridization. Probe Intensity Analysis (see Analysis Types below) use test:reference ratios to detect copy number changes. Advantages: one can "scan" an entire genome very rapidly; high sensitivity. Disadvantages: cannot detect inversions or complex rearrangements; cannot determine genomic location of copy number gains (and in some cases losses); resolution not as high as sequencing. Another very popular method for detecting structural variation.
Answer Lists using this Answer Code
| Answer List | Answer List Name | Externally Defined |
|---|---|---|
| LL4048-6 | Structural variant analysis method | N |
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