LA26417-8
Optical mapping
Active
Answer Description
An integrated set of methods and analyses which involve stretching DNA into a single filament, immobilizing it on a charged surface, complete digestion with a single restriction enzyme, optical observation of the resulting restriction pattern, and comparison of results against the expected restriction pattern based on a reference genome. Advantages: ability to detect location and nature of insertions, deletions, and inversions. Disadvantages: highly specialized; cannot alone determine the sequence content or genomic origin of abberant events.
Answer Lists using this Answer Code
| Answer List | Answer List Name | Externally Defined |
|---|---|---|
| LL4048-6 | Structural variant analysis method | N |
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