LOINC
Version 2.67

LP135722-9Human papilloma virus E6+E7 mRNAActive

Descriptions

LP135722-9   Human papilloma virus 16+18+31+33+35+39+45+51+52+56+58+59+66+68 E6+E7 mRNA
Most human papilloma virus (HPV) genomes encode for eight major proteins, six "early" (E1, E2, E3, E4, E6, and E7) and two "late" (L1 and L2). The "early" are regulatory in function. E6 and E7 genes in high-risk HPV genotypes are known as oncogenes because of their continuous expression, which leads to disruption of cell-cycle check points and cell genome instability through alteration of cellular p53 and retinoblastoma protein functions. Source: Regenstrief LOINC

LP135722-9   Human papilloma virus 16+18+31+33+35+39+45+51+52+56+58+59+66+68 E6+E7 mRNA
E6 and E7 are the HPV proteins associated with cancer. The HPV genome is composed of six early (E1, E2, E3, E4, E6, and E7) and two late (L1 and L2) proteins.[43] After the host cell is infected E1 and E2 are expressed first. High E2 levels repress expression of the E6 and E7 proteins. When the host and HPV genomes integrate, E2 function is disrupted, preventing repression of E6/E7.
Role in cancer
The E6/E7 proteins inactivate two tumor suppressor proteins, p53 (inactivated by E6) and pRb (inactivated by E7).[9] The viral oncogenes E6 and E7[44] are thought to modify the cell cycle so as to retain the differentiating host keratinocyte in a state that is favourable to the amplification of viral genome replication and consequent late gene expression. E6 in association with host E6-associated protein, which has ubiquitin ligase activity, acts to ubiquitinate p53, leading to its proteosomal degradation. E7 (in oncogenic HPVs) acts as the primary transforming protein. E7 competes for retinoblastoma protein (pRb) binding, freeing the transcription factor E2F to transactivate its targets, thus pushing the cell cycle forward. All HPV can induce transient proliferation, but only strains 16 and 18 can immortalize cell lines in vitro. It has also been shown that HPV 16 and 18 cannot immortalize primary rat cells alone; there needs to be activation of the ras oncogene. In the upper layers of the host epithelium, the late genes L1 and L2 are transcribed/translated and serve as structural proteins that encapsidate the amplified viral genomes. Once the genome is encapsidated, the capsid appears to undergo a redox-dependent assembly/maturation event, which is tied to a natural redox gradient that spans both suprabasal and cornified epithelial tissue layers. This assembly/maturation event stabilizes virions, and increases their specific infectivity.[45] Virions can then be sloughed off in the dead squames of the host epithelium and the viral lifecycle continues.[46] A 2010 study has found that E6 and E7 are involved in beta-catenin nuclear accumulation and activation of Wnt signaling in HPV-induced cancers.[47] Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Human papillomavirus, E6/E7 (Wikipedia)

Basic Part Properties

Name
Human papilloma virus 16+18+31+33+35+39+45+51+52+56+58+59+66+68 E6+E7 mRNA
Type
Component
Created On
2011-10-05
Construct for LOINC Short Name
HPV E6+E7 mRNA

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Language Variants Get Info

zh-CNChinese (CHINA)
人乳头瘤病毒 16+18+31+33+35+39+45+51+52+56+58+59+66+68 E6+E7 型 mRNA
Synonyms: HPV 16+18+31+33+35+39+45+51+52+56+58+59+66+68 E6+E7 型 mRNA
nl-NLDutch (NETHERLANDS)
Humaan papillomavirus 16+18+31+33+35+39+45+51+52+56+58+59+66+68 E6+E7 mRNA
it-ITItalian (ITALY)
Papilloma virus umano 16+18+31+33+35+39+45+51+52+56+58+59+66+68 E6+E7 mRNA
Synonyms: mRNA di E6+E7 papilloma virus umano
ru-RURussian (RUSSIAN FEDERATION)
Вирус папилломы человека 16+18+31+33+35+39+45+51+52+56+58+59+66+68 E6+E7 мРНК
es-ESSpanish (SPAIN)
ARN m de Papilomavirus humano 16+18+31+33+35+39+45+51+52+56+58+59+66+68 E6+E7
tr-TRTurkish (TURKEY)
Human papilloma virüsü 16+18+31+33+35+39+45+51+52+56+58+59+66+68 E6+E7 mRNA