LOINC
Version 2.68

LP14487-0ThyrotropinActive

Descriptions

LP14487-0   Thyrotropin
A glycoprotein hormone secreted by the adenohypophysis (anterior pituitary gland). Thyrotropin stimulates the thyroid gland by increasing the iodide transport, synthesis and release of thyroid hormones (thyroxine and triiodothyronine). Thyrotropin consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the pituitary glycoprotein hormones (TSH; Luteinizing hormone and FSH), but the beta subunit is unique and confers its biological specificity. Source: National Library of Medicine, MeSH 2006

LP14487-0   Thyrotropin
Thyrotropin (TSH) has three codes in LOINC which differ by their detection limits.

1) The so-called first-generation TSH test was of low sensitivity, such that it was not useful for diagnosing or following hyperthyroidism. It is no longer commercially available.

LOINC has a code with no specified detection limit.

3016-3 Thyrotropin [Units/volume] in Serum or Plasma

This code has existed since the first release of LOINC (in 1994). Today you should avoid mapping to it except when you are mapping old TSH tests whose sensitivity cannot be ascertained.

2) The so-called 2nd generation TSH has a detection limit of <= .05 mIU/L and is now the routine TSH test in most settings.

11579-0 Thyrotropin [Units/volume] in Serum or Plasma by Detection limit <= 0.05 mIU/L

It has the advantage over earlier tests in that it can detect both hyperthyroidism (reflected by an abnormally low TSH) and hypothyroidism, reflected by an abnormally high TSH.

3) A third-generation TSH with a detection limit of <= .005 mIU/L also exists.

Labs usually add high sensitivity or ultra-sensitive or 3rd generation to its name. It only offers advantage over the 2nd generation test in special cases. Because of its limited measurement range at the high end, it can require more work (extra dilution steps) to quantify the value of very high TSH levels, but it is widely available.

11580-8 Thyrotropin [Units/volume] in Serum or Plasma by high sensitivity Detection limit <= 0.005 mIU/L

LOINC includes codes for TSH tests that are reported in mass concentrations and molar concentrations. However, all current TSH test results are reported as mIU/L (or equivalent). Except in very special circumstances, the only TSH variables to which you should map are the two immediately above. Source: Regenstrief Help, LOINC Mapper's Guide to Top 2000+ US Lab Tests

Basic Part Properties

Name
Thyrotropin
Type
Component
Created On
2000-05-04
Construct for LOINC Short Name
TSH

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP14487-0

Language Variants Get Info

zh-CNChinese (CHINA)
促甲状腺激素
Synonyms: TSH;促甲状腺素;甲状腺刺激激素;甲状腺刺激激素（Thyroid Stimulating Hormone，TSH）
nl-NLDutch (NETHERLANDS)
TSH
et-EEEstonian (ESTONIA)
Kilpnääret stimuleeriv hormoon
Synonyms: Türotropiin
fr-BEFrench (BELGIUM)
Hormone thyréostimulante
Synonyms: TSH
fr-CAFrench (CANADA)
Hormone thyréostimulante
el-GRGreek (GREECE)
Θυρεοειδοτρόπος ορμόνη
Synonyms: TSH
it-ITItalian (ITALY)
Tireotropina
Synonyms: TSH
ru-RURussian (RUSSIAN FEDERATION)
Тиреотропин
es-ESSpanish (SPAIN)
Tirotropina
tr-TRTurkish (TURKEY)
Tirotropin