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LP14687-5Peanut agglutininActive


LP14687-5   Peanut agglutinin
Lectin purified from peanuts (ARACHIS HYPOGAEA). It binds to poorly differentiated cells and terminally differentiated cells and is used in cell separation techniques. Source: National Library of Medicine, MeSH 2006

LP14687-5   Peanut agglutinin
Peanut agglutinin (PNA) is plant lectin protein derived from the fruits of Arachis hypogaea. Peanut agglutinin may also be referred to as Arachis hypogaea lectin. Lectins recognise and bind particular sugar sequences in carbohydrates; peanut agglutinin binds the carbohydrate sequence Gal-β(1-3)-GalNAc. The name "peanut agglutinin" originates from its ability to stick together (agglutinate) cells, such as neuramidase-treated erythrocytes, which have glycoproteins or glycolipids on their surface which include the Gal-β(1-3)-GalNAc carbohydrate sequence.

Because peanut agglutinin specifically binds a particular carbohydrate sequence it finds use in a range of methods for cell biology and biochemistry. For example in PNA-affinity chromatography the binding specificity of peanut agglutinin is used to isolate glycosylated molecules which have the sugar sequence Gal-β(1-3)-GalNAc. Peanut agglutinin activity is inhibited by lactose and galactose which compete for the binding site.

Other uses include Potent anti-T cell activity, distinguishing between human lymphocyte subsets, tumour tissue determination for transitional mucosa malignancies, identification of mammalian-infective metacyclic promastigote Leishmania major parasites from other life cycle forms also found in the sandfly host. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Wikipedia

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Peanut agglutinin
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Language Variants Get Info

zh-CNChinese (CHINA)
Synonyms: PNA;花生凝集素(Peanut Agglutinin,PNA)
et-EEEstonian (ESTONIA)
Maapähkli aglutiniin
fr-BEFrench (BELGIUM)
Agglutinine d'arachide
fr-CAFrench (CANADA)
Agglutinine d'arachide
it-ITItalian (ITALY)
Arachidi, agglutinina
Synonyms: Agglutinina delle arachidi
Арахиса агглютинин
es-ESSpanish (SPAIN)
Aglutinina de cacahuete
Synonyms: PNA
tr-TRTurkish (TURKEY)
Yerfıstığı aglütinin