LOINC
Version 2.70

LP14697-4ThyroglobulinActive

Descriptions

LP14697-4   Thyroglobulin
Thyroglobulin (Tg) is a protein produced by and used entirely within the thyroid gland. Thyroglobulin is used by the thyroid gland to produce the thyroid hormones thyroxine (T4) and triiodothyronine (T3). Thyroglobulin is stored in the thyroid in follicle cysts surrounded by colloid cells. Via a reaction with the enzyme thyroperoxidase, iodine is covalently bound to tyrosine residues in thyroglobulin molecules, forming monoiodotyrosine (MIT) and diiodotyrosine (DIT). Thyroxine is produced by linking two moieties of DIT. Combining one particle of MIT and one particle of DIT produces triiodothyronine. Proteases in lysosomes digest iodinated thyroglobulin, releasing T3 and T4. Thyroglobulin levels in the blood can be used as a tumor marker for certain kinds of thyroid cancer. Thyroglobulin levels in the blood can also be elevated in cases of Graves Disease. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Thyroglobulin (Wikipedia)

LP14697-4   Thyroglobulin
Thyroglobulin (Tg) is a glycoprotein homodimer produced by the thyroid gland. It is important in the synthesis of thyroxine and triiodothyronine, and is where the inactive forms of thyroid hormone and iodine are stored. Mutations in the Tg gene cause thyroid dyshormonogenesis resulting in goiter, and can be associated with moderate to severe congenital hypothyroidism. Polymorphisms in the Tg gene are associated with susceptibility to autoimmune thyroid diseases such as Graves disease or Hashimoto thyroiditis. [NCBI Gene ID:7038] Tg is an established tumor marker used in the diagnosis of differentiated thyroid carcinoma. [PMID: 9543128] Source: Regenstrief LOINC

Basic Part Properties

Name
Thyroglobulin
Type
Component
Created On
2000-05-04
Construct for LOINC Short Name
Thyroglob

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP14697-4

Language Variants Get Info

zh-CNChinese (China)
甲状腺球蛋白
Synonyms: TG;甲状球蛋白;甲状腺球朊;甲状腺球蛋白(Thyroglobulin,TG,Tg);甲状腺球蛋白特异性
nl-NLDutch (Netherlands)
thyreoglobuline
et-EEEstonian (Estonia)
Türeoglobuliin
fr-BEFrench (Belgium)
Thyroglobuline
Synonyms: hTG
fr-CAFrench (Canada)
Thyroglobuline
el-GRGreek (Greece)
Θυρεοσφαιρίνη
it-ITItalian (Italy)
Tireoglobulina
ru-RURussian (Russian Federation)
Тиреоглобулин
es-ESSpanish (Spain)
Tiroglobulina
tr-TRTurkish (Turkey)
Tiroglobulin