LOINC
Version 2.73

LP15182-6TacrolimusActive

Descriptions

LP15182-6   Tacrolimus
Tacrolimus (also known as FK-506 or Prograf) is a macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis. It has strong immunosuppressive properties and is commonly used to prevent allograft rejection in transplant recipients. One of its modes of action is to prevent T-lymphocyte activation. Source: National Library of Medicine, MeSH 2006

LP15182-6   Tacrolimus
Tacrolimus (also called FK-506 or fujimycin, Prograf, Advagraf, or Protopic) is amacrolide lactone, calcineurin inhibitor immunosuppresent used mainly after allogeneic organ transplant to lower the risk of organ rejection. It possesses strong immunosuppressive activity by preventing the activation by of T-lymphocytes in response to antigenic or mitogenic stimulation. Tacrolimus is also used in a topical preparation in the treatment of atopic dermatitis (eczema), severe refractory uveitis after bone marrow transplants, exacerbations of minimal change disease, TH2-mediated diseases such as Kimura's disease, and the skin condition vitiligo. There are potentially severe side effects from doses that are either too low or too high; inadequate tacrolimus concentrations may result in rejection of the transplanted organ, while high levels may lead to severe adverse effects includin nephrotoxicity, neurotoxicity, gastrointestinal disturbances, diabetogenesis, hypertension and malignant complications. [Wikipedia:Tacrolimus] Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Tacrolimus

Basic Part Properties

Name
Tacrolimus
Type
Component
Created On
2000-05-04
Construct for LOINC Short Name
Tacrolimus

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP15182-6

Language Variants Get Info

zh-CNChinese (China)
他克莫司
Synonyms: 普乐可复
nl-NLDutch (Netherlands)
tacrolimus
et-EEEstonian (Estonia)
Takroliimus
fr-BEFrench (Belgium)
Tacrolimus
fr-CAFrench (Canada)
Tacrolimus
el-GRGreek (Greece)
Τακρόλιμους
it-ITItalian (Italy)
Tacrolimus
Synonyms: FK-506
ru-RURussian (Russian Federation)
Такролимус
Synonyms: FK-506
es-ESSpanish (Spain)
Tacrolimus
Synonyms: FK506;FK-506
tr-TRTurkish (Turkey)
Takrolimus
Synonyms: FK-506