LOINC
Version 2.67

LP15461-4Cancer Ag 15-3Active

Descriptions

LP15461-4   Cancer Ag 15-3
CA 15-3 is a tumor marker for breast cancer. It is derived from MUC1. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, CA 15-3

LP15461-4   Cancer Ag 15-3
Cancer antigen 15-3 (CA 15-3) is a mucin molecule and blood tumor marker used to gauge the response to treatment of invasive breast cancer. CA 15-3 is encoded by the MUC1 gene and is a transmembrane glycoprotein. CA 15-3 may contribute to the growth of breast tumors by preventing tumor cell cytolysis by cytotoxic T-cells or lymphokine-activated cells. It may also block the proliferation of T-cells by causing apoptosis. In addition, CA 15-3 has been found to be expressed over the entire cell in malignant breast tissue while normal breast tissue expresses CA 15-3 only on the apical side of the glanudular epithelial cells. The presence of CA 15-3 is not unique to patients with breast cancer, but can also be found in patients with lung, colorectal, ovarian, and pancreatic cancers. Patients with primary tumors tend to have lower levels of CA 15-3, though the average concentration and percentage of patients goes up as the tumor stage or size of the tumor increases. While only a small number of recurrences of local or regional tumors result in an increased CA 15-3 level, over 70% of patients with remote metastasis have much higher CA 15-3 levels. [PMID: 10505206] Source: Regenstrief LOINC

Basic Part Properties

Name
Cancer Ag 15-3
Type
Component
Created On
2000-05-04
Construct for LOINC Short Name
Cancer Ag15-3

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP15461-4

Language Variants Get Info

zh-CNChinese (CHINA)
癌抗原 15-3
Synonyms: CA 153;CA 15-3;MUC-1 基因相关抗原 CA 15-3;癌 Ag 15-3
nl-NLDutch (NETHERLANDS)
CA15.3
Synonyms: kanker Ag 15-3
et-EEEstonian (ESTONIA)
Kasvajaantigeen CA 15-3
fr-BEFrench (BELGIUM)
Ag carbohydraté 15-3
Synonyms: Ca 15.3
fr-CAFrench (CANADA)
Ag carbohydraté 15-3
el-GRGreek (GREECE)
Καρκινικό αντιγόνο 15-3
Synonyms: CA 15‐3
it-ITItalian (ITALY)
Cancro, Ag 15-3
Synonyms: Antigene 15-3 di cancro
ru-RURussian (RUSSIAN FEDERATION)
Раковый Аг 15-3
es-ESSpanish (SPAIN)
Antígeno CA 15-3
Synonyms: Ag CA-15-3 asociado al gen MUC-1
tr-TRTurkish (TURKEY)
Kanser Ag 15-3