LOINC
Version 2.73

LP157213-2Centromere protein A AbActive

Description

LP157213-2   Centromere protein A Ab
Centromere protein A, also known as Histone H3-like centromeric protein A (CENP-A), replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. It is required for recruitment and assembly of kinetochore proteins, progression of mitosis and segregation of chromosomes. [UniProt:P49450] Anti-CENP-A antibodies are a marker of systemic sclerosis (SSc), a multisystem autoimmune connective tissue disorder that is characterized by vascular abnormalities, excessive collagen synthesis, and autoantibodies to nuclear and nucleolar proteins. Approximately 20-40% of patients with SSc are positive for anti-CENP-A or-B antibodies, and these patients are at higher risk of developing pulmonary arterial hypertension, but a lower risk of early interstitial lung disease, at least early in the disease course. [PMID:26455561] Source: Regenstrief LOINC, PMID: 26455561

Basic Part Properties

Name
Centromere protein A Ab
Type
Component
Created On
2012-08-21
Construct for LOINC Short Name
Centromere A Ab

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https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP157213-2